植物雌激素防治牙周炎的研究进展

Prevention and treatment for periodontitis by phytoestrogens

雌激素代谢紊乱是牙周炎的全身促进因素。应用雌激素替代治疗可增加牙槽骨骨量,延缓牙周病进程,然而其安全性难以评估。植物雌激素是一种天然的雌激素类似物,包括大豆异黄酮、香豆素、木脂素等,可与人体内雌激素受体结合发挥相应的雌激素效应。近年来,越来越多的研究证据表明,外源性补充植物雌激素有可能缓解牙周炎症和组织破坏,为牙周炎治疗提供新的思路。本文就植物雌激素在牙周炎症及牙周组织破坏方面的研究进展进行综述。

Estrogen metabolism disorder is the systemic promoting factor of periodontitis.Application of estrogen replacement treatment can increase the alveolar bone mass and delay the progression of periodontal disease.However,its biosafety is difficult to assess.Phytoestrogens are natural plant compounds that are similar to estrogen,including soy isoflavones,coumarins and lignans,etc.They have estrogen-like activity by binding with estrogen receptor.Recently,increasing evidence have been found indicating exogenous phytoestrogens could relieve periodontal inflammation and tissue destruction.They offer a promising therapy for periodontitis.Thus,we colligate correlated documents and write the review.