肿瘤中lncRNAs和circRNAs关系的研究进展

Study on relationship between lncRNAs and circRNAs in tumor

随着基因测序技术的发展,越来越多的长链非编码RNAs(lncRNAs)和环状RNAs(circRNAs)在肿瘤的研究中被发现,并引起学者对它们持续的关注。lncRNAs和circRNAs同属非编码RNA,在起源和功能上两者存在着密切关系,现均被证实在肿瘤发生、发展中发挥重要作用。该文总结了lncRNAs和circRNAs国内外的最新研究进展,专注于它们之间的关系,进一步了解与区分,以期更好识别肿瘤生物标志物。

With the development of whole genome and transcriptome sequencing technologies,a growing body of long noncoding RNAs(lncRNAs)and circular RNAs(circRNAs)has been identified and is receiving increasing attention.LncRNAs and circRNAs are non-protein encoding transcripts whose functions are crucial for advancing our comprehensive understanding of biological processes in human health and diseases,specifically tumor.And there is a close relationship between circRNAs and lncRNAs in their origin and function.In this paper,we have reviewed the recent advances of lncRNAs and circRNAs in tumor by focusing on their relationships,which may help to distinguish them and identify tumor biomarkers further.