摘要
目的:探讨三七注射液保护糖尿病大鼠肾脏的机制。方法:建模,18只糖尿病大鼠随机分为糖尿病组(DM组,6只)、三七注射液组(PNS组,6只)、雷公藤甲素组(TPL组,6只),另设对照组(NC组)6只,灌胃持续4周。测定肾脏肥大指数;HE观察肾组织形态学变化;测定肾组织中一氧化氮(NO)、一氧化氮合酶(NOS)和诱导型一氧化氮合酶(i NOS)水平。结果:与DM组比较,PNS组肾脏肥大指数降低,肾组织病理明显改善,肾内NO水平、NOS和i NOS活性降低。结论:三七注射液通过抑制NO及其合酶的表达对糖尿病大鼠的肾脏有一定的保护作用。
Objective:To investigate the mechanism of the Sanqi injection(三七注射液)on kidney in diabetic rats.Methods:18 diabetic rats were randomly divided into the diabetes group(DM group,6 rats),Sanqi injection group(PNS group,6 rats),triptolide group(TPL group,6 rats).6 rats in the control group were administrated for 4 weeks.The renal hypertrophy index was measured.The morphological changes of renal tissue was observed by HE.The levels of nitric oxide(NO),nitric oxide synthase(NOS)and inducible nitric oxide synthase(iNOS)were determined.Results:Compared with DM group,the renal hypertrophy index in PNS group was decreased,renal pathology was significantly improved,and NO level,NOS and iNOS activity were decreased in kidney.Conclusion:The Sanqi injection has certain protective effects on the kidney of diabetic rats by inhibiting the expression of NO and its synthase.
出处
《中医临床研究》
2018年第22期17-18,共2页
Clinical Journal Of Chinese Medicine
基金
南阳市科技攻关项目
2017JCQY009
