Apelin-13与急性脑梗死患者发病及90天预后相关性分析

Relationship between Apelin-13 and the onset and the prognosis at 90d of patients with acute cerebral infraction

目的探讨孤独G蛋白偶联受体配体-13(Apelin-13)水平与急性脑梗死(ACI)患者发病及90d预后的关系。方法选择2016年6月至2016年11月期间被本院神经内科收治的162例ACI患者(病例组)及107例同期健康体检者(对照组),进行血清Apelin-13水平检测,同时采集相关的临床资料。病例组随访至发病第90d,并进行mRS评分。结果病例组男性患者例数、吸烟史、高血压病、糖尿病、冠心病的比例及糖化血红蛋白均高于对照组,血清Apelin-13水平低于对照组(均P<0.05)。Logistic回归分析显示男性患者例数、高血压病、冠心病、糖化血红蛋白、血清Apelin-13水平均与ACI患者发病密切相关(P<0.05)。预后不良组入院NIHSS评分、梗死体积高于预后良好组,血清Apelin-13水平低于预后良好组(P<0.05)。Logistic回归分析显示入院NIHSS评分及血清Apelin-13水平与ACI患者90d预后密切相关(P<0.05)。结论 ACI患者入院血清Apelin-13水平较对照组低,并且血清Apelin-13水平与ACI患者发病及90d预后密切相关。

Objective To explore relationship between Apelin-13 and the onset and the prognosis at 90d of patients with acute cerebral infraction(ACI).Method 162 patients with ACI(case group)and 107 healthy controls(control group)were selected as the research object from June 2016 to November 2016,and the level of serum Apelin-13 was detected.Clinical data was also collected.And the modified Rankin Scale score(mRS)was conducted at 90d after the onse.Results Proportion of male patents,smoking history,hypertension,diabetes mellitus,coronary heart disease were significant higher than control group,and the level of serum Apelin-13 was significant lower than control group(P<0.05).Multiple Logistic regression indicated that proportion of male patents,hypertension,coronary heart disease and the level of serum Apelin-13 was significantly associated with ACI(P<0.05).Compared with good outcome group,National Institutes of Health Stroke Scale(NIHSS)score on admission,infraction volume were significant higher and the level of serum Apelin-13 was significant lower(P<0.05).NIHSS score on admission and the level of serum Apelin-13 were significantly associated with 90d outcome of ACI after multiple Logistic regression(P<0.05).Conclusion The level of serum Apelin-13 in patients with ACI was lower than control group,and was significantly associated with the onset and 90d outcome of ACI.