干扰素在中枢神经系统退行性疾病中的作用

The roles of interferons(IFNs) in neurodegenerative diseases

干扰素(Interferons,IFNs)在神经系统退行性疾病中作用机制复杂。IFNs受体在神经元与胶质细胞中广泛表达,提示IFNs在神经系统中发挥重要作用。然而,IFNs在中枢神经系统中的功能,特别是在相关疾病中的作用机制仍不清楚。近年来,越来越多的研究关注IFNs在中枢神经系统中的作用以及对神经元和胶质细胞的调控机制。本文主要就IFNs的结构、功能和疾病的关系进行综述。

The roles that interferons(IFN s)play in neurodegenerative diseases are com plicated.IFN receptors(IF N A R)are widely expressed in neurons and g lia cells,w hich suggest that IFN s play an im portant role in the nervous system.However,the flin c-tions of IFNs remain unclear in central nervous system,especially in neurodegenerative diseases.This article reviewed recent progress on the structure and functions of IFN s as well as their roles in neurodegenerative diseases.