通心络联合阿托伐他汀治疗H型高血压颈动脉粥样硬化的效果

Efficacy of Tongxinluo and atorvastatin on carotid atherosclerosis of H type hypertension

目的:研究通心络联合阿托伐他汀治疗H型高血压颈动脉粥样硬化的效果。方法:选择我院在2015年11月-2016年11月收治的100例H型高血压颈动脉粥样硬化患者为观察对象,将患者随机分为两组,分别为对照组和治疗组,每组50例患者。两组患者均使用阿托伐他汀治疗,治疗组患者在此治疗基础上使用通心络联合治疗,对比两组患者治疗前后血脂、D-二聚体(D-dime)、纤溶酶抑制物(PAI-1)、半胱氨酸(Hcy)、斑块面积、内膜中层厚度(IMT)和斑块总积分,并且对比两组患者的血压指数。结果:两组患者治疗前后收缩压无明显差异,治疗之后,对照组患者收缩压及舒张压为(129.52±8.24)mmHg、(80.52±8.24)mmHg,治疗组患者收缩压及舒张压为(134.25±10.41)mmHg、(76.51±8.21)mmHg,明显治疗组患者治疗之后的收缩压及舒张压改善情况优于对照组,数据差异具有统计学意义(P<0.05)。两组患者治疗之前的一般水平无明显差异(P>0.05),对照组患者的CHO、TG、HDL、LDL、PAI-1、D-dime、Hcy水平分别为(4.62±0.94)mmol/L、(1.51±0.31)mmol/L、(2.37±0.58)mmol/L、(3.51±0.24)mmol/L、(71.25±4.31)ng/L、(430.25±36.25)μg/L、(15.31±2.50)μmol/L,治疗组患者的CHO、TG、HDL、LDL、PAI-1、D-dime、Hcy水平分别为(3.91±0.57)mmol/L、(1.04±0.16)mmol/L、(2.04±0.61)mmol/L、(3.00±0.21)mmol/L、(6.20±3.11)ng/L、(311.02±28.34)μg/L、(9.31±1.57)μmol/L,以此可以看出来,治疗组患者的一般水平改善情况优于对照组,数据差异具有统计学意义(P<0.05)。结论:通心络联合阿托伐他汀在治疗H型高血压颈动脉粥样硬化过程中具有良好的效果,能够有效改善患者的血压及血脂,还能够改善患者的半胱氨酸、纤溶酶抑制物、斑块面积等情况,值得临床推广使用。

Objective:To study the effect of Tongxinluo(通心络)and atorvastatin on carotid atherosclerosis of H type hypertension.Methods:100 patients in our hospital from November 2015 to November 2016 were selected as observation subjects,and were randomly divided into the control group and treatment group,50 patients in each group.Both groups were treated with atorvastatin,and the treatment group was treated with Tongxinluo(通心络)more.Blood lipids,D-dime,PAI-1,Hcy,patch area,IMT and plaque total score were compared before and after treatment in two groups.The blood pressure index in two groups was compared.Results:There was no significant difference in systolic pressure before and after treatment between two groups.After treatment,the systolic pressure and diastolic pressure in the control group were(129.52±8.24)mmHg and(80.52±8.24)mmHg respectively,and those in the treatment group were(134.25±10.41)MmHg and(76.51±8.21)MmHg respectively.The improvement of systolic pressure and diastolic blood pressure in the treatment group was better than the control group,and the difference was statistically significant(P<0.05).There was no significant difference in general level between two groups before treatment(P>0.05),CHO,TG,HDL,LDL,PAI-1,D-dime and Hcy in the control group were(4.62±0.94)mmol/L,(1.51±0.31)mmol/L,(2.37±0.58)mmol/L,(3.51±0.24)mmol/L,(71.25±4.31)ng/L,(430.25±36.25)μg/L and(15.31±2.50)μmol/L respectively,and those in the treatment group were(3.91±0.57)mmol/L,(1.04±0.16)mmol/L,(2.04±0.61)mmol/L,(3.00±0.21)mmol/L,(6.20±3.11)ng/L,(311.02±28.34)μg/L and(9.31±1.57)μmol/L respectively.The improvement of general level in the treatment group was better than the control group,with statistically significant differences(P<0.05).Conclusion:Tongxinluo(通心络)and atorvastatin shows a good effect,can effectively improve blood pressure and blood lipids,but also can improve the patient’s cysteine,fibrinolytic enzyme inhibitor,plaque area and so on,worthy of clinical use.