TNF-α和IL-6在新生血管性青光眼发病过程中的作用

Relation of serum and aqueous humor TNF-α and IL-6 with the process of neovascular glaucoma

目的:通过检测新生血管性青光眼(neovascular glaucoma,NVG)患者血清及房水中TNF-α、IL-6的浓度,探讨它们在NVG发病中的作用。方法:选择2017-01/2018-01期间在我院眼科住院治疗的新生血管性青光眼患者64例64眼作为试验组,同期住院开角型青光眼(POAG)、年龄相关性白内障(ARC)患者作为对照组,检测三组患者血清及房水中TNF-α、IL-6水平,进行单因素方差分析和相关性分析。结果:NVG组患者血清与房水中TNF-α、IL-6水平明显高于POAG组,差异均有统计学意义(P<0.05);与ARC组比较,差异有显著的统计学意义(P<0.01);NVG组患者房水及血清中TNF-α与IL-6呈显著正相关(r=0.642、0.415,P<0.05)。结论:NVG患者血清及房水中TNF-α、IL-6均显著升高,TNF-α、IL-6在视网膜新生血管的发生、发展中起重要作用。

·AIM:To investigate the relationship of TNF-αand IL-6 with the pathogenesis and development of the neovascular glaucoma(NVG).·METHODS:Totally 64 eyes of 64 NVG patients,58 eyes of 58 primary open angle glaucoma(POAG)patients and 56 eyes of 56 age-related cataract(ARC)patients were enrolled in our Hospital from January 2017 to January 2018.The periphery blood was collected from all the patients and 0.3mL aqueous humor was collected during the surgery from each eye.The levels of TNF-αand IL-6 in serum and aqueous humor of the three groups were measured by ELISA.·RESULTS:The concentrations of TNF-αand IL-6 in aqueous humor and serum in NVG patients were higher than those in POAG patients as well as in ARC patients,with significant differences among the three groups(P<0.05).The TNF-αand IL-6 in aqueous humor and serum in NVG patients were significantly positively correlated(r=0.642,0.415;P<0.05).·CONCLUSION:The aqueous and serum TNF-αand IL-6 are considerably higher in NVG patients than those in POAG patients and ARC patients,suggesting that TNF-αand IL-6 play important roles in the pathogenesis and development of the NVG.