急性CSC荧光素渗漏点近红外自身荧光图像特征

Characteristics of near-infrared fundus autofluorescence at the leakage site in acute central serous chorioretinopathy

目的:观察急性中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)荧光渗漏点近红外自身荧光(near-infrared fundus autofluorescence,NIR-FAF)的图像特征。方法:将25例25眼确诊为急性CSC患者纳入本回顾性研究,平均44.52±6.17岁。使用共焦激光扫描检眼镜进行眼底荧光素血管造影和NIR-FAF检查。观察荧光渗漏点的NIR-FAF图像特征。结果:急性CSC患眼荧光渗漏点NIR-FAF有4种表现:无异常、弱荧光、斑驳荧光和强荧光。25例患眼中,FFA荧光渗漏点NIR-FAF图像中仅1眼(4%)无明显异常,余24眼(96%)均有异常改变,其中点状弱荧光7眼,片状弱荧光10眼,片状斑驳荧光5眼,片状强荧光2眼。所有患眼均存在与浆液性视网膜脱离区相对应的异常NIR-FAF,其中弱荧光17眼,斑驳荧光8眼。结论:急性CSC荧光渗漏点具有特征性NIR-FAF改变。NIR-FAF成像术能够作为早期发现急性CSC患眼RPE异常的一种快速、有效和无创性的检查方法。

·AIM:To investigate the characteristics of near-infrared fundus autofluorescence(NIR-FAF)at the leakage site in acute central serous chorioretinopathy(CSC).·METHODS:Twenty-five eyes of the 25 patients diagnosed with acute CSC(mean age 44.52±6.17 years)were included in this retrospective study.Fundus fluorescein angiography and NIR-FAF imaging were performed using a confocal scanning laser ophthalmoscope.The imaging features of NIR-FAF at the leakage site were analyzed.·RESULTS:There were four patterns of NIR-FAF at the leakage site in acute CSC eyes:no NIR-FAF abnormal changes,hypoautofluorescence(hypo-AF),mottled autofluorescence(AF)and hyperautofluorescence(hyper-AF).Only 1 eye(4%)among 25 eyes of NIR-FAF imaging at the leakage site had no obvious abnormalities,while other 24 eyes(96%)had abnormal changes.Among them,7 eyes had dot-like hypo-AF,10 eyes had expanded hypo-AF,5 eyes had expanded mottled AF and the remaining 2 eyes had expanded hyper-AF.All eyes had abnormal NIR-FAF corresponding to the area of the serous retinal detachment,including 17 eyes with hypo-AF and 8 eyes with mottled AF.·CONCLUSION:There are characteristic NIR-FAF changes at the leakage sites of acute CSC eyes.NIR-FAF photography can be used as a fast,effective and non-invasive method for the early detection of RPE abnormality in acute CSC.