复合功能性金属离子生物活性玻璃特征、功能及应用

Functional metal ions-containing bioactive glass: characteristics, functions and applications

背景:生物活性玻璃具有良好的细胞相容性、骨传导和骨诱导活性,在骨缺损治疗方面应用前景广大。目的:为最大化开发和利用生物玻璃的生物学特性,也为进一步加强疾患的局部精准治疗,一系列将生物玻璃与金属元素复合以提高其生物学功能的课题研究不断涌现。方法:通过检索万方数据库、中国知网及PubMed数据库,获得有关功能性生物活性玻璃的文献,并从中筛选出通过复合金属离子以进一步加强生物玻璃功能的文献。结果与讨论:生物活性玻璃目前可以复合的多种功能性金属离子,从而赋予其抗菌、促血管生成、磁热抗肿瘤等多种功能,展望了功能性生物活性玻璃在骨科的应用研究前景。

BACKGROUND:Bioactive glass is biocompatible,osteoconductive and osteoinductive.Therefore,bioactive glass has great potential in the treatment of bone defects.OBJECTIVE:To carry out a series of researches on the combination of bioactive glass and metal elements so as to maximize the development and utilization of bioactive glasses and to boost the development of local precision treatments.METHODS:By retrieval of WanFang,CNKI,PubMed databases,literatures on functional bioactive glass were obtained,in which studies addressing the further functional enhancement of bioactive glass in combination with metal ions were screened out.RESULTS AND CONCLUSION:Current bioactive glass can be combined with a variety of functional metal ions,thereby endowing it with antibacterial,pro-angiogenic,and magnetocaloric functions.Moreover,this review prospects the application of functional bioactive glass in orthopedics.