扁桃体淋巴瘤470例病理类型构成分析

Tonsillar lymphoma: analyses of pathological types of 470 cases

目的探讨扁桃体淋巴瘤的病理类型构成、年龄和性别特点。方法回顾性分析首都医科大学附属北京友谊医院病理科2007年4月~2016年11月活检取自扁桃体的470例淋巴瘤会诊病例资料,从患者性别、发病年龄、病理类型等方面进行分析总结。结果 470例淋巴瘤患者中,男性266例,女性204例,男女比为1.30∶1,平均年龄49岁(2~90岁),41~70岁为高发年龄。470例扁桃体淋巴瘤中非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)467例(99.63%)、霍奇金淋巴瘤(Hodgkin’s lymphoma,HL)3例(0.64%)。3例HL分别为:淋巴细胞为主HL、结节硬化型经典HL、混合细胞型经典HL各1例。在NHL中,B细胞淋巴瘤占85.9%,T/NK细胞淋巴瘤占14.1%。构成比高的前5位分别是弥漫大B细胞淋巴瘤-非特殊类型(diffuse large B cell lymphoma-non-specific type,DLBCL-NOS)237例(50.75%),男女比为0.94∶1,中位年龄52岁;滤泡性淋巴瘤65例(13.92%),男女比为1.2∶1,中位年龄52岁;套细胞淋巴瘤28例(6.00%),男女比为4.6∶1,中位年龄60岁;黏膜相关淋巴组织边缘区B细胞淋巴瘤22例(4.71%),男女比为1.4∶1,中位年龄57岁;外周T细胞淋巴瘤-非特殊类型20例(4.28%),男女比为4∶1,中位年龄58岁。结论扁桃体淋巴瘤中几乎均为NHL,B细胞淋巴瘤远多于T/NK细胞淋巴瘤;DLBCL-NOS占比最高,各类型扁桃淋巴瘤也具有一定年龄和性别特点。

Purpose To investigate the pathological type of tonsillar lymphoma and the characteristics of age and gender.Methods The clinical data of 470 cases of tonsillar lymphoma were retrospectively analyzed from the Department of Pathology,Beijing Friendship Hospital Affiliated to Capital Medical University during April 2007 to November 2016 biopsies,including the gender,age,pathological type and other aspects.Results The 470 cases included 266 malesand 204 female,male to female ratio was 1.30∶1,with the average age of 49 years(2-90 years),peak age of 41 to 70 years.467 cases of tonsillar lymphoma were non-Hodgkin’s lymphoma(NHL)(99.63%)and 3 cases of Hodgkin’s lymphoma(HL)(0.64%).Of the 3 cases of HL there were one case of lymphocyte predominant,nodular sclerosis and mixed cell type,each.In NHL,B cell lymphoma accounted for 85.9%and T/NK cell lymphoma 14.1%.The top five constituents were diffuse large B cell lymphoma-non-specific type(237 cases,50.75%,the ratio of male to female of 0.94∶1,and the median age of 52 years),65 cases of follicular lymphoma(13.92%,the ratio of male to female of 1.2∶1,and the median age of 52 years),28 cases of mantle cell lymphoma(6%,the ratio of male to female of 4.6∶1,and the median age of 60 years),22 cases of marginal zone B cell lymphoma of mucosa associated lymphoid tissue(4.71%,the ratio of male to female of 1.4∶1,and the median age of 57 age),and 20 cases of peripheral T-cell lymphoma non-specific type(4.28%,the ratio of male to female of 4∶1,and the median age of 58 years).Conclusion In tonsillar lymphoma,almost all are NHL,and B cell lymphoma is more frequently found than T/NK cell lymphoma.Diffuse large B cell lymphoma is the highest proportion type,and all types of lymphoma also have certain age and gender characteristics.