摘要
目的:利用静息态功能磁共振成像(rs-fMRI)功能连接张量(FCT)比较睁眼和闭眼状态下的脑功能活动的差异。方法:对48例健康被试在睁眼和闭眼状态下行全脑rs-fMRI扫描。将所有数据进行预处理,获得每例被试基于体素水平的脑组织功能连接张量图,并计算全组平均各项异性指数(FA)和迹(trace)。采用配对t检验比较功能连接张量的特征指标(FA和trace)在不同静息状态(睁眼和闭眼)下的差异。结果:FA值和trace值在睁眼和闭眼状态下差异有统计学意义的脑区均位于大脑枕叶区域,其中FA值在睁眼状态下较闭眼状态下略低(单体素P=0.01,Z=2.33,校正后团簇的P<0.05),而trace值在睁眼状态下较闭眼状态下略高(单体素:P=0.01,Z=2.33;团簇:校正后P<0.05)。除了视觉区之外,其它部位的功能连接张量在两种状态之间具有很好的一致性。结论:静息态功能磁共振成像可反映睁眼和闭眼状态下脑视觉区的功能变化。
Objective:To compare the difference of brain functional activity between eyes open(EO)and eyes closed(EC)conditions using functional correlation tensor(FCT)in resting-state functional MRI(rs-fMRI).Methods:Forty-eight healthy volunteers were included in this study,each one underwent eyes-open and eyes-closed rs-fMRI scanning.Voxel-wise FCT maps for each subject were constructed after pre-processing steps.Based on the group level,the average values of FCT indexes including FA and trace in eyes-open and eyes-closed conditions were obtained and compared using paired t-test.Results:On both FA and trace maps,only occipital cortex showed significant difference between the two resting-state,lower FA values(voxel level:P=0.01,Z=2.33;mass level:corrected P<0.05)and higher trace values(voxel level:P=0.01,Z=2.33;mass level:corrected P<0.05)were found under eyes-open condition.Besides,there was good consistency for FCT of other brain regions between the two conditions.Conclusion:Resting-state functional MRI may reflect the functional changes of occipital cortex under eyes-open and eyes-closed conditions.
作者
尤攀
张建鹏
YOU Pan;JIAN Peng;MA Qiang(Department of Radiology,the People's Hospital of Yanchi,Ningxia 751500,China)
出处
《放射学实践》
北大核心
2018年第8期833-837,共5页
Radiologic Practice
关键词
磁共振成像
功能成像
静息态
功能连接张量
眼部运动
Magnetic resonance imaging
Functional imaging,resting-state
Functional correlation tensor
Motion of eyes