疱疹穿刺引流结合干扰素对手足口病患儿T淋巴细胞亚群水平及炎症因子的影响

Effect of herpes puncture drainage combined with interferon on the level of T lymphocyte subsets and inflammatory factors in children with hand foot and mouth disease

目的探讨疱疹穿刺引流结合干扰素对手足口病患儿T淋巴细胞亚群水平与炎症因子的影响及临床疗效。方法选取2016年12月~2017年12月期间本院收治的118例手足口病患儿为研究对象。随机分为对照组和观察组,各59例。所有患儿入院后均给予常规对症治疗,对照组给予利巴韦林治疗,观察组在对照组的基础上给予疱疹穿刺引流联合干扰素治疗。比较两组患儿治疗前后T淋巴细胞亚群水平与炎症因子变化情况及临床疗效。结果两组治疗前T淋巴细胞亚群水平及炎症因子比较差异无统计学意义;治疗后CD3+、CD4+、CD4+/CD8+水平均升高、CD8+、TNF-α、IL-6、IL-10均降低(P<0.05);观察组治疗后CD3+、CD4+、CD4+/CD8+水平均高于对照组、CD8+、TNF-α、IL-6、IL-10均低于对照组(P<0.05);观察组总有效率明显高于对照组(P<0.05)。结论应用疱疹穿刺引流联合干扰素增强了手足口病患儿机体免疫功能,抑制了机体炎症反应,临床疗效显著,值得推广应用。

Objective To investigate the effect of herpes puncture drainage combined with interferon on the level of T lymphocyte subsets and inflammatory factors in children with hand foot and mouth disease.Methods 118 cases of hand foot and mouth disease in our hospital during the period of December 2016 to December 2017 were selected as the research object.The control group and the observation group were randomly divided into 59 cases.All children received routine symptomatic treatment after admission,while the control group was given ribavirin treatment.The observation group was given herpes puncture drainage combined with interferon on the basis of the control group.The changes of T lymphocyte subsets and inflammatory factors before and after treatment in the two groups were compared and the clinical effects were compared.Results The two groups before treatment the level of inflammatory cytokines and T lymphocyte subsets were no significant difference;CD3^+,CD4^+,CD4^+/CD8^+after treatment,CD8^+levels were elevated,TNF-alpha,IL-6 and IL-10 decreased(P<0.05);the observation group after treatment CD3^+,CD4^+and CD4^+/CD8^+levels were higher than the control group,CD8^+,TNF-alpha,IL-6 and IL-10 were lower than the control group(P<0.05);the total efficiency of the observation group was significantly higher than the control group(P<0.05).Conclusion Herpes puncture and drainage combined with interferon enhanced the immune function of children with hand foot mouth disease,and inhibited the inflammatory reaction.The clinical efficacy was significant,and it is worthy of popularization and application.