加味黄连温胆汤治疗频发室性早搏痰火扰心型临床研究

Clinical observation of modified Huanglian Wendan decoction in the treatment of frequent ventricular premature beat with Tanhuo Raoxin

目的:观察痰火扰心型频发室性早搏患者应用加味黄连温胆汤联合琥珀酸美托洛尔缓释片临床疗效。方法:纳入60例痰火扰心型频发室性早搏患者,随机分为两组,各30例。对照组进行常规抗心律失常药物治疗,应用琥珀酸美托洛尔缓释片;观察组在应用琥珀酸美托洛尔缓释片的基础上,加用加味黄连温胆汤治疗,疗程均为4周。对比两组治疗疗效,对两组治疗前后24小时动态心电图室性早搏次数、中医证候积分进行比较,并观察两组患者所发生的不良反应及治疗前后血常规、肝肾功能。结果:观察组改善室性早搏有效率为83.33%,对照组为66.67%,观察组疗效优于对照组(P<0.05)。观察组改善中医证候有效率为86.67%,对照组为70.00%,观察组疗效优于对照组(P<0.05)。观察组24小时动态心电图室性早搏次数改善情况、中医证候积分改善情况明显优于对照组(P<0.05)。观察组和对照组均出现轻度胃部不适、恶心等症状,观察组1例,对照组2例,经对症治疗后均缓解。治疗前后两组患者的血常规、肝肾功能均未见异常。结论:在治疗痰火扰心型频发室性早搏中,联合应用加味黄连温胆汤治疗,效果更显著。

Objective:To observe the clinical efficacy of modified Huanglian Wendan decoction combined with metoprolol succinate sustained-release tablets in patients with frequent ventricular premature beat caused by Tanhuo Raoxin.Methods:60 patients with frequent ventricular premature beat caused by phlegm-fire were randomly divided into two groups,control group and observation group,with 30 cases in each group.The control group was treated with conventional antiarrhythmic drugs and metoprolol succinate sustained-release tablets were used.The observation group was treated with modified Huanglian Wendan decoction on the basis of metoprolol succinate sustained-release tablets,and the course of treatment was 4 weeks.Compare the therapeutic effect of two groups,and compare the 24-hour dynamic electrocardiogram ventricular premature beat frequency and TCM syndrome score before and after the treatment of two groups.We also observed the adverse reactions of two groups,blood routine and liver and kidney function before and after treatment.Results:The effective rate of improving ventricular premature beat in the observation group was 83.33%and 66.67%in the control group,and the curative effect in the observation group was superior to that in the control group(P<0.05).The effective rate of improving TCM syndromes in the observation group was 86.67%and 70.00%in the control group,and the curative effect in the observation group was better than that in the control group(P<0.05).The improvement of 24-hour dynamic electrocardiogram ventricular premature beats and TCM syndromes in the observation group were also significantly better than those in the control group(P<0.05).Mild stomach discomfort and nausea were observed in both the observation group and the control group,and 1 case in the observation group and 2 cases in the control group were relieved after symptomatic treatment.There were no abnormalities in blood routine and liver and kidney function in both groups before and after treatment.Conclusion:In the treatment of frequent ventricular premature beats caused by Tanhuo Raoxin,the combined application of modified Huanglian Wendan decoction has one more significant effect.