期刊文献+

人血浆脂蛋白相关磷脂酶A2与脑梗死的相关性研究

下载PDF
导出
摘要 目的探究人血浆脂蛋白相关磷脂酶A2(Lp-PLA2)与脑梗死的相关性。方法选取神经内科住院脑梗死患者150例作为实验组,时间为2015年6月-2016年6月,同时选取150例健康体检者作为对照组,这2组受检者均接受Lp-PLA2检测,并对检测的结果进行分析。结果实验组血浆Lp-PLA2水平与hs-CRP水平明显高于对照组(P<0.05);随着脑梗死患者疾病加重,其血浆Lp-PLA2水平与hs-CRP水平逐渐升高(P<0.05);脑梗死预后良好组的血浆Lp-PLA2水平与hs-CRP水平明显低于预后不良组(P<0.05);脑梗死患者的病情程度与其血浆Lp-PLA2水平和hs-CRP水平呈正相关的关系,其预后与血浆Lp-PLA2水平和hs-CRP水平呈负相关的关系(P<0.05)。结论Lp-PLA2在脑梗死患者疾病发生、发展过程中起着重要的作用,其与患者的疾病程度与预后有着较为密切的联系,可以为患者的治疗以及预后评估提供依据。
机构地区 无锡解放军第
出处 《湖南中医药大学学报》 CAS 2018年第A01期430-430,共1页 Journal of Hunan University of Chinese Medicine
  • 相关文献

参考文献5

二级参考文献36

  • 1Leach C A,Hickey D M,Ife R J,et al.Lipoprotein-associated PLA2 inhibition-a novel,nonlipid lowering strategy for atherosclerosis therapy.[J].Farmaco Jan,2001,56(1-2):45-50.
  • 2Oei H H,Sayed-Tabatabaei F A,Hofman A,et al.The association between angiotensin-converting enzyme gene polymorphism and-coronary calcification.The Rotterdam Coronary Calcification Study[J].Atherosclerosis,2005,182 (1):169-173.
  • 3The Lp-PLA2 Studies Collaboration,Ballantyne C,Cushman M,et al.Collaborative meta-analysis of individual participant data from observational studies of Lp-PLA2 and cardiovascular diseases[J].Eul J Cardiovasc Prev Rehabil,2007,14(1):3-11.
  • 4Ballantyne C M,Hoogeveen R C,Bang H,et al.lipoprotein-associated phospholipase A2,high-sensitivity C-reactive protein,and risk for incident coronary heart disease in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study[J].Circulation,2004,109(7):837-842.
  • 5Rodriguez-Colon S M,Mo J,Duan Y,et al.Metabolic syndrome clusters and the risk of incident stroke; the atherosclerosis risk in communities (ARIC) study[J].Stroke,2009,40(1):200-205.
  • 6The Lp-PLA2 Studies Collaboration,Ballantyne C,Cushman M,Psaty B,Furberg C,K T Khaw,Sandhu M,et al.Collaborative meta-analysis of individual participant data from observational studies of Lp-PLA2 and cardiovascular diseases.[J].Eur J Cardiovasc Prev Rehabil,2007,14(1):3-11.
  • 7Persson M,Hedblad B,Nelson J J,et al.Elevated Lp-PLA2 levels add prognostic information to the metabolic syndrome on incidence of cardiovascular events among middle-aged nondiabetic subjects[J].Arterioscler Thromb Vase Biol,2007,27(6):1411-1416.
  • 8Mannheim D,Herrmann J,Versari D,et al.Enhanced expression of Lp-PLA2 and lysophosphatidylcholine in symptomatic carotid atherosclerotic plaques[J].Stroke,2008,39(5):1448-1455.
  • 9Macphee CH, Nelson J, Zalewski A. Role of lipoprotein-associated phospholipase A2 in atherosclerosis and its potential as a therapeutic target[J]. Curr Opin Pharmacol, 2006, 6(2): 154-161.
  • 10Hart RG, Halperin JL. Atrial fibrillation and stroke: concepts and controversies [ J ]. Stroke, 2001, 32 ( 3 ) : 803-808.

共引文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部