沙利度胺与CAG方案治疗老年急性髓系白血病的效果研究

目的:探究沙利度胺联合CAG方案应用于治疗老年急性髓系白血病患者的临床治疗效果和用药安全性。方法:选择我院中2015年8月至2017年4月间收治的急性髓系白血病老年患者108例作为研究对象,按照患者入院日期,单双号对患者进行随机分组,分别命名为对照组和实验组,每组中均包含54例患者;对照组患者采用单纯CAG方案进行治疗,实验组患者则应用沙利度胺联合CAG方案进行治疗,对比两组患者的用药不良反应,评估患者疗效。结果:所有患者在进行两个周期诱导缓解治疗后,对照组完全缓解率为36(66.67%),而实验组完全缓解率为40(74.07%),组间差异无统计学意义(P<0.05),不具有可比性。但实验组患者的恶心、呕吐以及治疗不良反应较对照组有明显减轻,组间差异具有统计学意义(P<0.05)。结论:将沙利度安与CAG方案联合应用于治疗老年急性髓系白血病患者的治疗过程中,虽然不能明显提高患者的治疗效果,但能够有效减轻患者的治疗不良反应,缓解患者的呕吐、恶心症状。对提高患者的治疗适应性,具有积极意义,值得推广使用。

objective:To investigate the clinical therapeutic effect and safety of CAG regimen in the treatment of elderly patients with acute myeloid leukemia.Methods:108 elderly patients with acute myeloid leukemia admitted between August 2015 and April 2017 were randomly divided into control group and experimental group.Results:The complete remission rate of the control group was 36(66.67%)after two cycles of induction remission,while the complete remission rate of the experimental group was 40(74.07%).There was no statistically significant difference between the two groups(P<0.05).However,the nausea,vomiting and adverse reactions in the experimental group were significantly reduced compared with the control group,and the difference between the groups was statistically significant(P<0.05).Conclusion:The degree of anxiety and Sally CAG chemotherapy used in the treatment of treatment of elderly patients with acute myeloid leukemia,although not significantly improve patient outcomes,but can effectively reduce the adverse reaction in the treatment of patients,alleviate the patient’s symptoms of vomiting,nausea.The treatment of patients with high adaptability,has positive significance,is worth promote the use of.