老年男性前列腺增生与血清25-羟维生素D水平的相关性探讨

目的:观察老年男性前列腺增生与血清25-羟维生素D水平的相关性。方法:本次选取我院2016年6月15日-2017年6月18日收治的前列腺增生患者100例作为研究对象,将其按照血清25-羟维生素D水平分为两组,观察组(大于或等于50nmol/L),对照组(小于50nmol/L),并对两组患者的血清25-羟维生素D水平分布情况、前列腺特异性抗原、游离前列腺特异抗原、前列腺体积、国际前列腺症状评分进行观察和评价。结果:观察组患者的前列腺特异性抗原、游离前列腺特异抗原与对照组相比无明显差异(P>0.05);观察组患者的前列腺体积、国际前列腺症状评分高于对照组(P<0.05)。结论:老年男性前列腺增生与血清25-羟维生素D水平呈负相关,为此临床上可采用维生素D、维生素D受体激动剂等药物治疗前列腺增生所引起的下尿路梗阻。

Objective:To investigate the correlation between prostatic hyperplasia and serum 25-,hydroxy vitamin D levels in elderly men.Methods:100 cases of BPH patients in our hospital from June 15,2016 to June 18th,2017 were selected as the object of study,and they were divided into two groups according to serum 25-and hydroxy vitamin D levels,The observation group(greater than or equal to 50nmol/L),control group(less than 50nmol/L),and two groups of patients with serum 25-hydroxyvitamin D distribution,prostate specific antigen and free prostate-specific antigen,prostate volume,international prostate symptom score were observed and evaluated.Results:there was no significant difference between observation group and prostate specific antigen in patients with prostate specific antigen and the control group(P>0.05);prostate volume,international prostate symptom score in observation group was higher than the control group(P<0.05).Conclusion:the elderly male prostate hyperplasia was negatively correlated with serum 25-hydroxyvitamin D levels,therefore can be used on clinical vitamin D,vitamin D receptor agonists for the treatment of benign prostatic hyperplasia caused by lower urinary tract obstruction.