青年脑卒中与阻塞性睡眠呼吸暂停低通气综合征的相关性研究进展

目的:研究青年脑卒中与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的相关性。方法:选取62例2016年10月至2017年10月在我院治疗的脑卒中合并OSAHS患者,将其列为观察组,再选择62例同期在我院治疗的脑卒中患者,将其列为对照组。给两组患者均进行睡眠监测,并对其进行睡眠分期。观察并比较两组患者的睡眠质量、睡眠结构、认知功能以及嗜睡程度。结果:在睡眠质量方面,观察组患者AHI高于对照组,其夜间平均动脉血氧饱和度(SaO2)和夜间最低动脉血氧饱和度(SaO2)与对照组相比均有所降低,观察组LAT延长,并且观察组患者夜间呼吸事件有明显的增多,均存在明显差异(P<0.05);在睡眠结构方面,观察组的醒觉时间、N1期和N2期有明显延长,而N3期和REM期的时间明显缩短,均存在明显差异(P<0.05);在认知功能和嗜睡程度评分方面,观察组ESS评分高于对照组,而MMSE评分低于对照组,差异显著(P<0.05)有统计学意义。结论:青年脑卒中伴有OSAHS患者与脑卒中患者相比较,前者的夜间睡眠质量极差,其睡眠结构比较乱。认知功能有明显下降,并且白天表现出了明显的嗜睡症状。

Objective:To study the correlation between young stroke and obstructive sleep apnea hypopnea syndrome(OSAHS).Methods:62 patients with stroke and OSAHS who were treated in our hospital from October 2016 to October 2017 were selected as the observation group,and 62 patients with stroke who were treated in our hospital in the same period were selected as the control group.Sleep monitoring was carried out in all two groups and the sleep stages were carried out.The quality of sleep,sleep structure,cognitive function and the degree of drowsiness were observed and compared between the two groups.Results:the sleep quality of patients in the observation group,AHI was higher than the control group,the nocturnal mean arterial oxygen saturation(SaO2)and the lowest arterial oxygen saturation(SaO2)were decreased compared with the control group,the observation group LAT prolonged,and the patients in the observation group were breathing at night events significantly increased,there were significant differences(P<0.05);in the sleep structure,the observation group awake time,N1 and N2 were significantly prolonged,while N3 and REM significantly shorten the time,there were significant differences(P<0.05);in terms of cognitive function and sleepiness score,ESS score of observation group was higher than that of control group.While the MMSE scores were lower than the control group,the difference was significant(P<0.05)was statistically significant.Conclusion:compared with stroke patients with OSAHS,the quality of nocturnal sleep in the former is very poor and the sleep structure is disorderly.The cognitive function was significantly decreased and the somnolence symptoms were obvious during the day.