基于NF-κB信号通路探讨中医药防治心肌缺血再灌注损伤的研究进展

Research progress of prevention and treatment of MIRI by tranditional Chinese medicine based on NF-κB signaling pathway

心肌缺血再灌注损伤(MIRI)是缺血心肌在恢复血流灌注后损伤反而加重的现象。随着溶栓、介入以及心脏外科手术技术的不断发展,MIRI显著增加,影响再灌注治疗的临床疗效。目前认为MIRI的发生机制与过氧化损伤、钙超载、炎症反应等有关,其中,核转录因子-κB(NF-κB)作为重要的转录因子,调控相关因子的转录,介导MIRI的进展。近年来,中医药基于NF-κB信号通路防治MIRI的研究逐渐增多,文章分别从中药单体及有效组分、复方与中成药、中药注射剂以及中医针灸疗法等方面对其研究现状作一总结。

Myocardial ischemia.reperfusion injury(MIRI)is a phenomenon that the myocardial injury aggravates after the restoration of blood perfusion.With the continuous development of thrombolysis,interventional and cardiac surgical techniques,MIRI is significantly increased,affecting the clinical efficacy of reperfusion therapy.At present,it is thought that the mechanism of MIRI is related to the damage of peroxide,calcium overload and inflammatory reaction,among which,NF-κB acts as an important transcription factor and regulates the transcription of related factors guide the progress of MIRI.In recent years,traditional Chinese medicine based on the NF-κB signaling pathway to prevent and cure MIRI research gradually increased.This article summarizes the research status of traditional Chinese medicine monomers and effective components,compound,Chinese patent medicine,traditional Chinese medicine injection and acupuncture therapy.