中药在局部中晚期宫颈鳞癌中的应用研究

Role of traditional Chinese medicine in locally-advanced cervical squamous carcinoma

目的探究中药在局部中晚期宫颈鳞癌中的应用。方法将124例初发初治的Ⅱb~Ⅲb期宫颈鳞癌患者随机分为中药联合治疗组和对照组,中药联合治疗组予以中药联合肿瘤深部热疗及同期放化疗;对照组仅行肿瘤深部热疗及同期放化疗。比较两组治疗后的总有效率、生活质量、血清鳞状上皮细胞癌抗原(SCC-Ag)、肝肾功能及不良反应。结果两组治疗后SCC-Ag水平比较有差异(P<0.05),两组治疗前后的SCC-Ag水平组间比较有差异(P<0.05),两组不良反应发生率比较有差异(P<0.05)。结论中药联合热疗及同期放化疗可提高局部中晚期宫颈鳞癌患者的生活质量,减轻不良反应。

Objective To explore the role of traditional Chinese medicine(TCM)in treatment of locallyadvanced cervical squamous cell carcinoma.Methods Totally 124 patients of stageⅡb-Ⅲb cervical squamous cancers were randomly divided into a combined TCM group(62 cases)and a control group(62 cases).The former group was treated with combined treatment which included TCM,thermotherapy and concurrent radiochemotherapy;the latter group received thermotherapy and concurrent radiochemotherapy.The total effective rate,the quality of life,serum level of squamous cell carcinoma antigen(SCC-Ag),hepatorenal functions and adverse reactions after treatments were compared.Results After treatment,the serum level of SCC-Ag was significantly different between the combined TCM group and the control group(P<0.05).In both groups,the serum level of SCC-Ag was significantly different before and after treatment(P<0.05).The incidences of adverse reactions were different between the two groups(P<0.05).The KPS score in the combined TCM group was significantly higher than that in the control group(P<0.05).However,there were no significant differences in the total effective rates or hepatorenal functions between the two groups(P>0.05).Conclusions Traditional Chinese medicine combined with thermotherapy and radiochemotherapy can improve the quality of life and decrease the adverse reactions of the patients with locally-advanced cervical squamous carcinoma.