复方丹参片联合多奈哌齐治疗阿尔茨海默病的临床疗效研究

Study of compound Danshen tablets combined with Donepezil on Alzheimer's disease

目的探讨复方丹参片联合多奈哌齐治疗阿尔茨海默病(AD)的安全性和有效性。方法选取广西壮族自治区江滨医院AD患者共100例,随机数字表法分为观察组和对照组,每组50例。对照组给予多奈哌齐治疗,观察组给予复方丹参片联合多奈哌齐治疗。观察组与对照组治疗前、治疗后1个月、治疗后3个月的简易精神状态量表(MMSE)评分、AD认知功能评定量表(ADAS-cog)评分、日常生活能力量表(ADL)评分、血清谷氨酸(Glu)水平、血清天冬氨酸(Asp)水平,均采用重复测量设计的方差分析。统计不良反应发生率。结果 (1)不同时间点间的MMSE评分、ADAS-cog评分、ADL评分、血清Glu水平、血清Asp水平有差异(P<0.05)。(2)观察组与对照组的MMSE评分、ADAS-cog评分、ADL评分、血清Glu水平、血清Asp水平有差异(P<0.05),观察组与对照组比较MMSE评分较高,ADAS-cog评分、ADL评分、血清Glu水平、血清Asp水平较低。(3)观察组与对照组的MMSE评分、ADAS-cog评分、ADL评分、血清Glu水平、血清Asp水平变化趋势有差异(P<0.05)。观察组和对照组不良反应发生率比较,差异无统计学意义(P<0.05)。结论复方丹参片联合多奈哌齐治疗AD的效果确切,其机制可能与抑制兴奋性氨基酸表达有关。

Objective To evaluate the efficacy and safety of compound Danshen tablets combined with Donepezil on Alzheimer's disease(AD).Methods One hundred AD patients were randomly divided into an observation group and a control group,with 50 cases in each group.The control group was treated with Donepezil,and the observation group was treated with compound Danshen tablets combined with Donepezil.Before treatment,1 month and 3 months after treatment,Mini-mental State Examination(MMSE)score,Alzheimer’s Disease Assessment Scale(ADAS-cog)score,activities of daily living(ADL)score,glutamic acid(Glu)level and aspartic acid(Asp)level of the two groups were analyzed by repeated measures.The incidences of adverse reactions of the two groups were counted.Results The MMSE score,ADAS-cog score,ADL score,serum Glu and Asp levels were different at different time points(P<0.05).The MMSE score,ADAS-cog score,ADL score,serum Glu and Asp levels were different between the observation group and the control group(P<0.05),the MMSE score of the observation group was higher than that of the control group,while the ADAS-cog score,ADL score,serum Glu and Asp levels of the observation group were lower than those of the control group.The variation trends of MMSE score,ADAS-cog score,ADL score,serum Glu and Asp levels were different at different time points(P<0.05).The adverse reaction rate was not statistically different between the two groups(P>0.05).Conclusions Compound Danshen tablets combined with Donepezil is effective for AD,its mechanism may be related to the inhibition of excitatory amino acid expression.