小胶质细胞-P2X4受体在神经病理性疼痛中的研究进展

Research progress of microglia-P2X4 receptor in neuropathic pain

神经病理性疼痛是一种具有代表性的慢性疼痛,对患者的心理及生理均具有极大的影响。周围神经损伤后脊髓小胶质细胞活化及其表面P2X4受体表达上调。P2X4受体是ATP受体的离子型亚型,在神经损伤的病理条件下受多种因素调节,而抑制小胶质细胞活化及其P2X4受体的高表达可减轻神经病理性疼痛,文章主要就小胶质细胞-P2X4受体在神经病理性疼痛发病过程中作用的研究进展进行综述。

Neuropathic pain is a typical chronic pain that has a great impact on the psychology and physiology of patients.Recent studies have shown that spinal microglial activation and the up-regulated expression of P2X4 receptor on its surface were occured after peripheral nerve injury.P2X4 receptor is an ionic subtype of ATP receptor,and was regulated by various factors under pathological conditions of nerve injury,such as chemokines,extracellular matrix fibronectin and interferon regulatory factor 5.Inhibition of microglial activation and P2X4 receptor expression can reduce neuropathic pain.Therefore,this article mainly describes the research progress of P2X4 receptor in the pathogenesis of neuropathic pain.