随机对照研究硝苯地平长效与短效制剂治疗妊娠高血压临床效果

Randomized controlled trial of long-acting and short-acting nifedipine in the treatment of pregnancy-induced hypertension

目的探讨分析硝苯地平长效与短效在妊娠高血压的治疗中的临床疗效。方法选取2017年5月~2018年5月医院收治的妊娠高血压患者90例,随机分为试验组和对照组,各45例。两组患者的治疗皆使用硫酸镁进行,在硫酸镁治疗的基础上,试验组加用长效硝苯地平片,对照组选用短效硝苯地平片。以7 d为一个疗程,对两组患者的血压、分娩状况、新生儿状况以及并发症发生率进行比较。结果经过不同方式的治疗,两组患者的收缩压、舒张压和动脉压皆有所好转,且试验组明显优于对照组(P﹤0.05)。此外,试验组患者的顺产率为84.44%,高于对照组的46.67%;新生儿未出现窒息、死亡等症状并顺利诞生的概率为93.33%,明显优于对照组(71.11%),P﹤0.05;试验组的并发症发生率(6.67%)则低于对照组(26.67%),差异具有统计学意义(P﹤0.05)。结论在妊娠高血压的疗程治疗中,长效硝苯地平的治疗效果明显优于短效硝苯地平,能有效控制产妇高血压,改善产妇分娩情况,值得临床应用和推广。

Objective To investigate the clinical efficacy of long-acting and short-acting nifedipine in the treatment of pregnancy-induced hypertension.Methods A total of 90 patients with gestational hypertension who were hospitalized from May 2017 to May 2018 were randomly divided into experimental group and control group,45 cases each.Both groups of patients were treated with magnesium sulfate.On the basis of magnesium sulfate treatment,long-acting nifedipine tablets were added to the test group,and shortacting nifedipine tablets were used in the control group.Taking 7 days as a course of treatment,blood pressure,delivery status,neonatal status,and incidence of complications in both groups were compared.Results After different treatments,systolic blood pressure,diastolic blood pressure and arterial pressure were improved in both groups,and the test group was significantly better than the control group(P<0.05).In addition,the patients in the trial group had 84.44%of the spontaneous delivery rate,which was 46.67%higher than that of the control group.The newborn had no symptoms of asphyxia and death and the birth probability was 93.33%,which was significantly better than the control group(71.11%).P<0.05;the complication rate of the experimental group(6.67%)was lower than the control group(26.67%),the difference was statistically significant(P<0.05).Conclusion In the course of treatment of pregnancy-induced hypertension,long-acting nifedipine treatment is significantly better than short-acting nifedipine,can effectively control maternal hypertension,improve maternal delivery,and is worthy of clinical application and promotion.