大黄贴敷联合复方聚乙二醇电解质散口服对便秘患者肠道准备给药时机的影响

The timing of rhubarb powder acupoint sticking therapy combining oral administration of compound polyethylene glycol electrolyte powder on intestine preparation before colonscopy in patients with constipation

目的探讨大黄贴敷神阙穴和天枢穴联合口服复方聚乙二醇电解质散(PGEP)在便秘患者肠道准备中的给药时机。方法选择行结肠镜检查的便秘患者300例,分3组,各100例。A组检查前1天晚上9点,行中药贴敷神阙穴和天枢穴,检查当天早上5~7点服完PGEP 139.12 g(2 000 ml);B组检查前1天晚上9点行中药贴敷神阙穴和天枢,检查当天上午10~12点服完相同剂量的PGEP;C组检查当天早上5点行中药贴敷神阙穴和天枢穴,早上5~7点服完相同剂量的PGEP。服药后4 h行结肠镜检查。应用Boston肠道准备量表(BBPS)评分,并对肠腔内气泡进行评分,比较3组患者肠道准备有效性、耐受性及安全性。结果 A组的肠镜检查时间(7.25±0.60)min明显短于B组(9.10±0.80)min和C组(10.50±0.55)min;A组的BBPS评分(8.50±0.35)分明显高于B组(7.35±1.25)分和C组(6.65±1.30)分;A组的肠腔内气泡评分(0.25±0.15)分明显低于B组(0.75±0.65)分和C组(0.55±0.50)分;A组肠道准备接受率、再次肠道准备接受率(96.00%、93.00%)明显高于B组(85.00%、70.00%)和C组(90.00%、88.00%);A组的总体不良反应评分(1.45±0.04)分明显低于B组(1.75±0.55)分和C组(1.60±0.25)分。差异均有统计学意义(P<0.05)。结论检查前1天晚上9点大黄穴位贴敷联合检查当天早上5~7点口服PGEP对便秘患者行结肠镜检查肠道准备效果好。

Objective To discuss the timing of administration of rhubarb powder sticking therapy on the Shenque and Tianshu acupoints in combination with oral administration of compound polyethylene glycol electrolyte powder(PGEP)in patients with constipation.Methods 300 cases of constipation were randomly divided into three groups,100 cases in each.Group A:rhubarb powder sticking therapy on Shenque and Tianshu acupoints at 9 p.m.of the day before colonscopy,and oral administration of PGEP at 5~7 a.m.of the day of colonscopy.Group B:rhubarb powder sticking therapy on Shenque and Tianshu acupoints at 9 p.m.of the day before colonscopy,and oral administration of PGEP at 10~12 a.m.of the day of colonscopy.Group C:rhubarb powder sticking therapy on Shenque and Tianshu acupoints at 9 p.m.of the day of colonscopy,and oral administration of PGEP at 10~12 a.m.Boston bowel preparation scale scores(BBPS)and bubbles in bowel lumen score were assessed.The effectiveness,tolerability and safety of intestinal preparation among the three groups were compared.Results The colonoscopy time in group A was significantly shorter than that in group B and C;the total score of BBPS in group A was significantly higher than that in group B and group C;the bubbles in bowel lumen score in group A was significantly lower than that in group B and group C;the intestinal acceptance rate and re-intestinal acceptance rate in group A was significantly higher than group B and group C;the overall adverse reaction scores in group A was significantly lower than that in group B and group C;the difference was statistically significant(P<0.05).Conclusion It is good effect of rhubarb powder sticking therapy on Shenque and Tianshu acupoints at 9 p.m.of the day before colonscopy,and oral administration of PGEP at 5~7 a.m.of the day of colonscopy on intestine preparation before colonscopy in patients with constipation.