NP-10 Potential Mechanism for Higher Stroke Risk in Diabetes

World Health Organization data show that the risk of cardiovascular and cerebrovascular disease in diabetic patients is 2 to 3 times that of non-diabetic patients,and 50%to 80%of diabetic patients eventually die of heart and cerebrovascular complications.Type 2 diabetes is currently considered as an independent risk factor for cerebral ischemic diseases,and about 20%of ischemic brain diseases are currently considered to be related to diabetes.The application of sulfonylurea drugs has been more than 60 years old.Although sulfonylurea drugs as a proportion of oral hypoglycemic drugs have declined with the continuous R&D and marketing applications of new hypoglycemic drugs,they currently account for the proportion still exceeds 40%and is the most widely used oral hypoglycemic drug.The correlation between the use of rosiglitazone and cardiovascular risk has led to uncertainty about the cardiovascular safety of different hypoglycemic drugs.With the increasing incidence of type 2 diabetes,it has become very important to clarify the vascular effects and safety of hypoglycemic drugs.We discuss the risk of stroke in patients with type 2 diabetes using sulfonylureas.