宫颈癌中DNMT1的高表达与其不良生存结局的相关性

Association of higher expression of DNMT1 in cervical cancer with poor survival outcome

目的探讨DNMT1在宫颈癌中的表达与宫颈癌生存结局的相关性。方法以102例接受初级治疗的宫颈癌患者为研究对象,采用免疫组化检测DNMT1的表达,以DNMT1阳性细胞百分比及其强度表示DNMT1的表达程度,以Cox比例风险模型评估DNMT1的表达程度与调整相关协变量后存活率之间的关系。结果与正常宫颈组织及癌旁组织相比,宫颈癌组织中DNMT1的表达明显升高,DNMT1阳性细胞比例升高,DNMT1强度评分升高,并与生存率差异显着相关(P=0.041 1)。结论宫颈癌组织中DNMET1的表达较高,其高表达与宫颈癌的不良预后相关。

Objective To evaluate the expression of Dna methyl transferase 1(DNMT1)in cervical cancer(CC)and its association with survival outcomes.Methods The study population consisted of 102 women treated for primary CC.The expression of DNMT1 was examined using immunohistochemistry,and the degree of expression of DNMT1 was expressed as a percentage of cell positive for DNMT1 and its intensity.Cox proportional hazards model was used to assess the relationship between the degree of expression of DNMT1 and overall survival after adjusting for relevant covariates.Results The expression of DNMT1 was significantly higher in CC cells compared to that in the normal cervical epithelium.A higher percentage of cells positive for DNMT1 and a higher intensity score for DNMT1 were significantly associated with poor survival outcome(P=0.041 1).Conclusion The expression of DNMT1 in cervical cancer tissue is high,and it is associated with poor prognosis of cervical cancer.