血液灌流联合血液透析对慢性肾衰竭患者血清炎性因子及肾功能的影响

Effect of hemoperfusion combined with hemodialysis on serum inflammatory factors and renal function in patients with chronic renal failure

目的 探讨血液灌流联合血液透析对慢性肾衰竭患者血清炎性因子及肾功能的影响。方法 选取本院2015年1月至2017年5月收治的106例慢性肾衰竭患者进行研究,按随机数字表法将其分为研究组与对照组,各53例。对照组患者在常规治疗基础上采用血液透析治疗,研究组在此基础上加用血液灌流治疗。治疗12周后,两组患者超敏C反应蛋白(hs-CRP)、白细胞介素1(IL-1)、白细胞介素6(IL-6)、肿瘤因子α(TNF-α)、甲状旁腺素(PTH)、血磷(P)、β2微球蛋白(β2-MG)、同型半胱氨酸(Hcy)、血肌酐(Scr)、尿素氮(BUN)表达水平比较。结果 治疗后,两组患者各炎症因子水平均明显降低,研究组IL-1、IL-6、hs-CRP及TNF-α均低于对照组,差异均有统计学意义(均P<0.05)。治疗后,两组患者肾功能指标均较治疗前降低,其中研究组β2-MG、BUN及Scr水平均低于对照组,差异均有统计学意义(均P<0.05)。治疗后,两组患者临床指标均较治疗前降低,其中研究组Hcy、PTH及P水平均低于对照组,差异有统计学意义(P<0.05)。结论 常规治疗基础上联合血液灌流与血液透析治疗可有效改善慢性肾衰竭患者肾功能及炎症反应。

Objective To investigate the effect of hemoperfusion combined with hemodialysis on serum inflammatory factors and renal function in patients with chronic renal failure.Methods 106 cases of patients with chronic renal failure in our hospital from January 2015 to May 2017 were chosen as experimental subjects,and were divided into control group and research group.The control group was treated with hemodialysis on the basis of routine treatment,the research group was treated with hemoperfusion on the basis of the control group.After 12 weeks of treatment,the expression levels of hs-CRP,IL-1,IL-6,TNF-α,PTH,P,β2-MG,Hcy,Scr,BUN were compared between the two groups.Results After treatment,the levels of inflammatory factors in the two groups significantly decreased,and the levels of IL-1,IL-6,hs-CRP,and TNF-αin the research group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of renal function indexes in the two groups significantly decreased,and the levels ofβ2-MG,BUN,and Scr in the research group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of clinical indexes in the two groups significantly decreased,and the levels of Hcy,PTH,and P in the research group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion Hemoperfusion combined with hemodialysis can effectively improve renal function and inflammatory response in patients with chronic renal failure.