骨质疏松治疗靶点:骨硬化蛋白及DKK-1与年龄、体质量指数、血糖和血脂之间的关系

Therapeutic targets of osteoporosis:correlation of age,body mass index,blood glucose and blood lipids with sclerostin and DKK-1

背景:研究显示,破骨细胞通过抑制骨硬化蛋白的表达发挥促进骨生成的作用,而调控骨吸收和骨形成平衡的关键在于骨吸收过程抑制骨硬化蛋白表达的程度。目的:分析成年男性骨硬化蛋白、DKK-1与年龄、体质量指数、空腹血糖、血脂之间的关系。方法:筛选健康体检的成年男性70例,46-67岁;收集其年龄、身高、体质量和既往病史等相关信息。检测空腹血糖、血脂,ELISA的方法测定血清骨硬化蛋白及DKK-1水平。结果与结论:(1)不同年龄、体质量指数、空腹血糖的受试者血清骨硬化蛋白水平差异有显著性意义(P<0.05);年龄57-67岁受试者血清DKK-1水平显著高于年龄46-56岁者(P<0.05);(2)血清骨硬化蛋白与DKK-1之间不存在相关性;(3)多元线性回归分析显示血清骨硬化蛋白与空腹血糖、体质量指数显著相关,血清DKK-1与年龄显著相关。因此,在进行骨硬化蛋白和DKK-1的相关研究时,需关注年龄、体质量指数、空腹血糖的影响。

BACKGROUND:Chondrocytes have been shown to promote osteogenesis by inhibiting the expression of sclerostin.The key to regulating the balance between bone resorption and bone formation is sclerostin expression inhibition in the process of bone resorption.OBJECTIVE:To analyze the correlation of age,body mass index,fasting blood glucose(FBG)and serum lipid with sclerostin and DKK-1 in adult men.METHODS:Seventy healthy men aged 46-67 years who received physical examination were enrolled.Age,body height,body mass and medical history were collected.The FBG and blood lipids were detected.The serum levels of sclerostin and DKK-1 were detected by ELISA.RESULTS AND CONCLUSION:(1)The level of sclerostin was significantly different among participants with different ages,body mass indices and FBG levels(P<0.05).The serum level of DKK-1 in 57-67-year-old participants was significantly higher than that in 46-56-year-old participants(P<0.05).(2)There was no relationship between serum sclerostin and DKK-1 levels.(3)Multiple linear regression analysis showed that serum level of sclerostin was significantly associated with FBG and body mass index.Serum level of DKK-1 was significantly associated with age.Therefore,much attention should be paid to age,FBG and body mass index in studies on sclerostin and DKK-1.