rhBMP-2联合Bio-oss骨粉在前牙美学区种植中的成骨效果

Osteogenic potential of recombinant human bone morphogenetic protein-2 combined with Bio-oss bone substitute in implant restorations in anterior esthetic region

目的研究重组人骨形态发生蛋白-2(recombinant human bone morphogenetic protein-2,rhBMP-2)联合Bio-oss骨粉在前牙美学区种植位点骨缺损的成骨效果。方法应用rhBMP-2联合Bio-oss骨粉修复骨缺损同期种植的患者12例共20颗种植体,统计术后6个月唇侧骨高度及骨板厚度的变化,戴牙后运用粉红色美学评分(pink esthetic score,PES)对软组织进行评价。结果 20颗种植体均种植成功,牙槽骨高度平均增长1.9 mm,其中17个种植位点(85%)均有不同程度的骨高度增长,1个种植位点在术前唇侧严重骨开裂的情况下,发生骨板的吸收,牙槽骨高度有所降低;2个种植位点的骨高度未发生明显改变;20个种植位点唇侧骨板厚度均大于1 mm,平均厚度为1.9 mm;PES平均分为9.8分。结论 rhBMP-2联合Bio-oss骨粉能较好地修复前牙美学区的骨缺损,取得良好的美学效果。

Objective To study the osteogenic potential of recombinant human bone morphogenetic protein 2(rhBMP-2)combined with Bio-oss bone substitute in the implant restoration of bone defects in the anterior esthetic region.Methods Twelve patients who underwent the immediate placement of 20 implants with a bone augmentation procedure using rhBMP-2 and Bio-oss were included in this study.Changes in the height and thickness of the buccal bone over 6 months were measured,and the soft tissue was evaluated using the pink esthetic score(PES)after crown placement.Results All 20 implants were successfully osseointegrated,and the average increase in bone height was 1.9 mm;different degrees of bone height growth were observed for 17(85%)implants sites.In one case,there was a severe bone fracture on the buccal side before the operation,resulting in bone plate resorption and decreased alveolar bone height.The bone height did not change significantly in 2 cases.The thickness of the buccal bone plate for all implants was greater than 1 mm.The average thickness was 1.9 mm,and the average PES was 9.8 points.Conclusion rhBMP-2 combined with Bio-oss bone substitute has a preferable effect on the restoration of bone defects in the anterior esthetic area,and can achieve good aesthetic effect.