维药买朱尼对犬种植体周围炎骨改建的实验研究

Experimental Study of Bone Remodelling after Maizhuni was Used to Treat Peri-implantitis in Dogs

目的:研究维药买朱尼对犬种植体周围炎骨界面改建的影响。方法:成功建立比格犬种植体周围炎模型后,随机分为3组,每组各3只,连续4周灌喂等量维药买朱尼、生理盐水、阿莫西林+甲硝唑,每日1次。4周后,监测3组探诊深度(PD)、种植体周围龈沟液(PISF),骨缺损量(骨缺损宽度DW、骨缺损深度DD、牙槽嵴水平BL)与组织学切片相结合观察种植体-骨界面改建情况。结果:生理盐水组分别与其他两组相比较,PD、PISF量、DW、DD、BL均有统计学意义(P<0.05),抗身素组和维药买朱尼组相比较,PD、PISF量、DW、DD、BL差异均无统计学意义。维药买朱尼组组织切片显示种植体颈部周围出现一定量的成骨细胞,骨髓区可见增生的新生骨细胞和骨小梁,生理盐水组种植体周围骨缺损较明显,骨缺损区可见纤维结缔组织。结论:维药买朱尼治疗种植体周围炎能较好的改善软组织炎症,同时促进新骨形成,但骨缺损修复并未达到理想效果。

Objective:To study the influence of maizhuni on implant-osseointegration interface remodeling of dog peri-implantitis.Methods:Peri-implantitis model of beagle dogs was successful established.Nine beagle dogs were randomly divided into three groups,which were given the same dose of Maizhuni,normal saline,and Amoxcillin capsules and M-etronidazole tablets.After a month,the implant-osseointegration interface remodeling was observed by monitoring the change of PD,PISF,bone defect(DW、DD and BL),and histology slices.Results:There were statistically significant differences in the index of PD,PISF,DW,DD,and BL content among three groups(P<0.05).There was no significant difference between the antibiotic and Maizhuni group in the index of PD,PISF,DW,DD,and BL.The histology slices of Maizhuni group showed that there had a certain amount of osteoblasts around the implant,and newly osteoblasts and bone trabecular were observed in the bone marrow area.Conclusion:Maizhuni can effectively improve the tissue inflammation status when treating peri-implantitis.However,the effect of bone defect repair is not ideal.