亚临床甲状腺功能减退与内脏脂肪组织的相关性研究

The relationship between subclinical hypothyroidism and visceral adipose tissue

目的研究亚临床甲状腺功能减退(SCH)与内脏脂肪组织的关系。方法从我院门诊体检中心及住院患者中招募满足入选标准的SCH患者68例及条件与之匹配的正常对照100例。比较2组性别、血压(SBP/DBP)、人体测量学指标、血脂、脂质蓄积指数(LAP)、内脏脂肪面积(VA)的差异。分析各个变量与促甲状腺激素(TSH)的相关性,探讨各个变量对SCH的影响。结果 SCH组腰围(WC)、腰臀比(WHR)、非高密度脂蛋白胆固醇(nonHDL-C)、三酰甘油(TG)、TSH、LAP、VA均高于正常对照组(P<0.05),高密度脂蛋白胆固醇(HDL-C)低于正常对照组(P<0.05)。2组间性别、年龄、体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)差异无统计学意义(P>0.05)。相关性分析显示TSH与WC、TG、nonHDL-C、LAP、VA呈正相关,与HDL-C呈负相关(P<0.05),与年龄、BMI、WHR、TC、LDL-C无明显相关性(P>0.05)。以是否发生SCH为因变量,以性别、WC、HDL-C、LAP、VA为自变量,进行二分类Logistic回归分析,结果显示女性、低水平HDL-C是发生SCH的危险因素,而VA、LAP对SCH的影响无统计学意义。结论 SCH人群血脂异常、VA增大较甲状腺功能正常人群更严重,提示SCH与腹型肥胖密切相关。

Objective To investigate the relationship between subclinical hypothyroidism(SCH)and visceral adipose tissue.Methods A total of 68 SCH subjects from medical examination center and inpatient department of our hospital and 100 healthy controls matched for age and sex were enrolled in this study.The patient gender,blood pressure(SBP/DBP),anthropometric measurements,lipid profile,lipid accumulation product(LAP)and visceral adipose area(VA)were compared between two groups.The Sperman’s correlation was used to analyze the correlation between thyroid stimulating hormone(TSH)and variables,and the Binary logistic regression analysis was used to analyze the impact of variables on SCH.Results The waist circumference(WC),waist to hip ratio(WHR),non high density lipoprotein cholesterol(nonHDL-C),three acylglycerol(TG),TSH,LAP and VA were higher in SCH subjects than that in the healthy controls(P<0.05),while HDL-C was lower in SCH subjects(P<0.05).There were no significant differences in sex,age,body mass index(BMI),SBP,DBP,total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)between two groups(P<0.05).Correlation analysis showed that TSH was positively correlated with WC,TG,nonHDL-C,LAP and VA,and negatively correlated with HDL-C(P<0.05).There was no significant correlation between TSH and age,BMI,WHR,TC and LDL-C(P>0.05).Binary logistic regression analysis showed that female and low level of HDL-C were risk factors of SCH,while the effects of VA and LAP on SCH were not statistically significant.Conclusion Our findings show that the dyslipidemia and VA increase are more serious in subjects with SCH than those with normal thyroid function and healthy controls,which suggest that SCH is closely related to abdominal obesity.