超声弹性成像联合检测CEA与CA15-3在乳腺癌诊断中的价值分析

Analysis on value of ultrasonic elastography combined with CEA and CA15-3 detection in diagnosis of breast cancer

目的探讨超声弹性成像(UE)联合检测癌胚抗原(CEA)与血清糖链抗原(CA15-3)在乳腺癌诊断中的价值。方法将海南省第三人民医院2015年4月至2017年2月收治的180例乳腺病患者依据检测结果分为乳腺癌组(78例)和乳腺良性肿瘤组(102例),将该院同期体检的100例健康妇女设为对照组;3组均进行UE检测,血清CEA与CA15-3水平检测;对比分析UE成像效果及UE、血清CEA、血清CA153 3种方法单一检测与联合检测在乳腺癌诊断中的价值。结果 UE检测乳腺癌特异度与敏感度高于常规超声,乳腺癌病灶超声弹性评分高于乳腺良性肿瘤病灶(P<0.05);乳腺癌组CEA与CA15-3水平高于乳腺良性肿瘤组与对照组(P<0.05);3种方法联合检测乳腺癌准确性高于单一检测(P<0.05)。结论 UE联合检测CEA与CA15-3能够提高乳腺癌诊断准确性。

Objective To investigate the value of ultrasonic elastography(UE)combined with carcinoembryonic antigen(CEA)and serum glucose chain antigen15-3(CA15-3)detection in the diagnosis of breast cancer.Methods One hundred and eighty cases of breast diseases in Hainan Provincial Third People′s hospital from April 2015 to February 2017 were divided into the breast cancer group(78 cases)and breast benign tumor group(102 cases)according to the examination results,and contemporaneous 100 healthy women undergoing physical examination in the hospital were selected as the control group;the three groups conducted the UE examination,and detection of serum CEA and CA15-3 levels;the UE imaging effect was contrastively analyzed.The values of single detection and combined detection of UE,serum CEA and CA153 in the diagnosis of breast cancer were comparatively analyzed.Results The specificity and sensitivity of UE for detecting breast cancer were significantly higher than those of conventional ultrasound,the UE score of breast cancer was significantly higher than that of benign tumor(P<0.05);the CEA and CA15-3 levels in the breast cancer group were significantly higher than those in the breast benign tumor group and control group(P<0.05);the accuracy of combined detection of three methods was significantly higher than that of single detection(P<0.05).Conclusion UE combined with CEA and CA15-3 detection can improve the accuracy of breast cancer diagnosis.