改良黄土汤联合西医治疗对老年PUB患者外周血GAS、IL-6和DAO水平的影响研究

Effect of integrated traditional Chinese and western medicine therapy for treating senile peptic ulcer bleeding on gastrointestinal hormones

目的观察改良黄土汤联合西医治疗对老年消化性溃疡出血(PUB)患者外周血胃泌素(GAS)、IL-6和二胺氧化酶(DAO)水平的影响。方法将56例老年PUB患者分为治疗组和对照组,每组28例,治疗组在对照组基础上加用改良黄土汤治疗。测定两组治疗前,治疗后72h及7d的血浆GAS、IL-6和DAO水平。结果与治疗前相比较,两组治疗后72h和7d时GAS、IL-6及DAO水平逐渐下降,差异有统计学意义(P<0.01),治疗组较对照组下降更明显(P<0.01)。结论 GAS、IL-6和DAO水平能够准确反映老年PUB患者胃肠黏膜修复状态,可作为老年PUB及溃疡愈合新的疗效检测指标。

Objective To observe the effect of integrated traditional Chinese and western medicine therapy for treating senile peptic ulcer bleeding(PUB)on peripheral blood gastrin(GAS),interleukin-6(IL-6)and diamine oxidase(DAO).Methods Fifty-six patients with senile PUB were randomly divided into the integrated traditional Chinese and western medicine treatment group(treatment group)and conventional western medicine treatment group(control group),28 cases in each group.The treatment group was added with improved Huangtu Decoction on the control group basis.The levels of plasma GAS,IL-6 and DAO before treatment and on 72 h and 7 d after treatment were detected in the two groups.Results The levels of GAS,IL-6 and DAO at 72 h and on 7 d after treat in both groups were gradually decreased compared with those before treatment,and the difference was statistically significant(P<0.01);but the decrease in the treatment group was more obvious than that in the control group(P<0.01).Conclusion The levels of GAS,IL-6 and DAO can accurately reflect the gastrointestinal mucosal repairing status in the patients with senile PUB,which can serve as the detection indicators of senile PUB and ulcer healing.