情绪异常大鼠模型的旷场行为实验在中医药领域的研究进展

A review of experimental studies on the behavior of rat models with abnormal emotion in Traditional Chinese Medicine

大鼠是较为常用的实验动物,旷场行为实验是检测动物情绪行为的一种常用的经典实验方法。涉及大鼠旷场行为实验的研究是这些年的热点,并呈上升趋势。旷场行为实验的条件会引起大鼠生理心理状态改变,影响大鼠行为的解读,从而影响疾病模型的判定。文章通过梳理近5年涉及大鼠旷场行为实验的研究文献,为选择较为合适大鼠旷场行为实验的条件以及合理的行为解读和模型判定作一综述。

Rat is a commonly used experimental animal.The open-field behavior test is one of the most commonly used methods to detect emotional behavior in animals,particularly for rats in recent years.The conditions of the open-field behavior test can cause changes in the physiological and psychological state of rats,affecting the interpretation of rat behavior,and thus affecting the determination of the rat model of diseases.To select suitable experimental conditions and achieve reasonable interpretation of behavior and an appropriate model,this article presents a review of the research literature on the open-field behavior test of rats published in the last 5 years.