慢性移植物抗宿主病相关干眼的研究进展

Research progress of dry eye secondary to chronic graft-versus-host disease

异基因造血干细胞移植术(HSCT)是目前治疗血液系统各种恶性或高危疾病的重要方法,而慢性移植物抗宿主病(Chronic graft versus host disease,cGVHD)是移植术后的常见并发症,是影响患者长期生存和生活质量的主要因素。干眼是cGVHD患者最常见的眼部损害,其发病机制尚不完全清楚,其诊断和治疗方案也无统一的标准。本文主要从免疫细胞失调、细胞因子失衡、眼表结构及功能损害等方面综述了cGVHD患者干眼发病机制的研究进展,阐述了cGVHD患者干眼的临床表现和诊断标准,并总结了近年来关于cGVHD患者干眼治疗方案的最新研究。

Allogeneic hematopoietic stem cell transplantation(HSCT)is currently an important method for the treatment of malignant or severe conditions of hematogenous disorders.Chronic graft versus host disease(cGVHD)after allogeneic HSCT is the main factor affecting recipient lifespan and life-quality.Dry eye is the common ocular manifestation of cGVHD,of which the mechanism is not well-defined and the uniform diagnostic criteria as well as treatment strategies are still lacking.Here,we summarized the updates of the mechanism of dry eye secondary to cGVHD with respects of the imbalance in immunocytes,cytokines as well as the morphological and functional damages of ocular surface,and elaborated its clinical features,diagnostic criteria,and current emerging systemic and local treatments.