胎盘来源microRNAs与子痫前期发病机制的研究进展

Progress in study on placenta-specific microRNAs and the pathogenesis of preeclampsia

子痫前期是妊娠期间特有的疾病之一,主要表现为妊娠20周后出现高血压并伴随有蛋白尿,发病机制可能包括胎盘的异常形成及母体的炎症反应等过程。MicroRNAs是一种短链非编码RNA,其作用是在转录水平上抑制下游靶基因的表达。一些研究提示microRNAs可作为潜在的生物学标志物评估疾病的发生发展及预后,而胎盘来源的microRNAs的异常表达是否与子痫前期的发生、发展密切相关仍存在争议。本文综述了胎盘来源的microRNAs与子痫前期发病机制的关系。

Preeclampsia,one of the pregnancy specific diseases,is a leading cause of new onset hypertension and proteinuria after 20 weeks.The preeclampsia pathogenesis includes abnormal placentation and maternal inflammatory response.MicroRNAs are a kind of non-coding RNAs that induce post-transcriptional suppression of target gene expression.In biomedical research,microRNAs can be used as the potential biomarkers to assess the development and prognosis of diseases.Whether the abnormal expression of placental-derived microRNAs is closely related to the occurrence and development of preeclampsia is still controversial.This article reviews the relationship between placental microRNAs and pathogenesis of preeclampsia.