添加Si对Mg-6Al-1Zn合金显微组织、力学性能、生物腐蚀和细胞毒性的影响（英文）

Effect of addition of Si on microstructure, mechanical properties, bio-corrosion and cytotoxicity of Mg-6Al-1Zn alloy

用机械合金化和热压法制备可降解的Mg-6Al-4Zn金属植入体。通过X射线衍射分析、透射电镜、压缩试验、浸泡试验、电化学测试和MTT比色法研究添加1%Si(质量分数)对Mg-6Al-1Zn合金显微组织、力学性能、生物腐蚀行为和细胞毒性的影响。结果显示,添加1%Si后,Mg-6Al-1Zn中形成了细小的多边形Mg2Si相,材料的抗压强度、伸长率和耐腐蚀性能提高,且骨肉瘤(Saos-2)细胞的细胞活性提高。根据MTT测试结果,释放出的镁离子没有细胞毒性。因此,添加1%Si提高了Mg-6Al-4Zn作为可降解植入体的综合性能。

The Mg-6Al-4Zn alloy was fabricated by mechanical alloying(MA)and hot pressing to serve as biodegradable metal implant.The influence of addition of 1%Si(mass fraction)on the microstructure,mechanical properties and bio-corrosion behavior of Mg-6Al-1Zn alloy was studied using X-ray diffractometry,transmission electron microscopy,compression test,as well as immersion,electrochemical test and MTT assay.The results showed that the addition of 1%Si to Mg-6Al-1Zn alloy led to the formation of fine Mg2Si phase with polygonal shape,and increased compressive strength,elongation and improved corrosion resistance.Furthermore,the cell viability of Saos-2 cells has been improved by addition of 1%Si to Mg-6Al-1Zn alloy.According to the results,the magnesium ions released in the methylthiazol tetrazolium(MTT)test have not shown any cell toxicity.All these indicated that the addition of 1%Si improved the properties of Mg-6Al-4Zn alloy for using as a biodegradable implant.