基于双波长的无创血红蛋白浓度监测仪的研制

Development of a non-invasive hemoglobin concentration monitor based on dual wavelength

设计一款双波长无创血红蛋白浓度监测仪,可实时监测人体血红蛋白浓度。总体设计分为软硬件设计及算法研究。软硬件设计采用STM32F407作为主控芯片,选择MAX30100作为传感器,使用LCD液晶屏显示实时波形,使用SD卡进行数据存储。算法研究主要采用希尔伯特黄变换(HHT)对脉搏波进行滤波处理,采用PCA算法和RELIEF算法相结合对提取的27个时域特征参数筛选筛选出12个特征参数,利用PLS建立血红蛋白模型。本次研究中,选择响应速度快、精度高的艾康生物技术公司生产的Mission HB便携式血红蛋白分析仪作为对照仪器。同时,随机选择31名志愿者在相同的实验条件下进行验证实验,对31组实验数据进行分析,得到相关系数为0.728,均方差为0.9416 g/d L。结果表明,本研究建立的双波长血红蛋白检测模型对血红蛋白浓度检测提供了一定的研究依据,对临床研究具有重要的意义。

To design noninvasive hemoglobin concentration detector with dual-wavelength and it can be used to monitor hemoglobin concentration in real time.The design was constitute of two parts,which were overall hardware,software design and algorithm research.It used STM32F407 as its main control chip,selected MAX30100 as sensor,used a LCD screen showing real-time wave,and adopted by the SD card to store the data.The algorithm mainly used the Hilbert transform(HHT)to filter the pulse wave.The ReliefF algorithm combined with PCA was used to screen out 12 feature parameters from the 27 extracted feature parameters.Finally,PLS was used to build a hemoglobin model.The Mission Hb hemoglobin analyzer produced by the Aiken Biotechnology company which responded quickly and with high precision,chose the instrument as a control instrument.A total of 31 volunteers were selected randomly to perform validation experiments under the same experimental conditions.The experimental data of 31 groups were analyzed and the correlation coefficient was 0.728,with a mean square error of 0.9416 g/dL.The comparative result shows that the two-wavelength hemoglobin detection model established in this study provides a certain basis for the detection of hemoglobin concentration and is of great significance to clinical research.