达比加群酯在小面积肺栓塞(单个肺叶阻塞)中的疗效观察

Effect of Dabigatran on Small Area Pulmonary Embolism(Single Lobe Obstruction)

目的观察达比加群酯在小面积肺栓塞(单个肺叶阻塞)中的疗效。方法随机选择2016年1月至2017年12月至我院进行小面积肺栓塞治疗的患者58例进行临床研究。使用随机数字法将患者分为观察组和对照组各29例,对照组患者给予常规氧气支持、镇痛、抗凝治疗,观察组患者在对照组治疗方案基础上给予达比加群酯胶囊进行治疗,各3个月,比较两组患者治疗前后呼吸频率(R)、心率(P)、PO2、PCO2等情况变化。结果两组患者治疗前R、P、PO2、PCO2均无明显差异(P>0.05),治疗后3个月,两组患者上述指标均明显好转,但观察组患者R、P均明显低于对照组,PO2、PCO2均明显高于对照组,且具有统计学差异(P<0.05)。结论达比加群酯在小面积肺栓塞中具有较好的临床疗效,能够明显改善患者的心肺功能。

Objective To observe the efficacy of dabigatran in the treatment of small area pulmonary embolism(single lobe obstruction).Methods 58 patients with small area pulmonary embolism treated in our hospital from January 2016 to December 2017 were randomly selected for clinical study.The patients were divided into the observation group and the control group with 29 cases.The patients in the control group were given routine oxygen support,analgesic and anticoagulant therapy.The patients in the observation group were treated with dabiga group on the basis of the control group for 3 months,and the respiratory frequency(R)and heart rate(P)before and after treatment in the two groups were compared),PO2,PCO2 and other changes.Results there was no significant difference in R,P,PO2 and PCO2 before treatment in the two groups(P>0.05).The above indexes were obviously improved in the two groups after 3 months of treatment,but the R and P in the observation group were significantly lower than those in the control group,and PO2 and PCO2 were significantly higher than those in the control group,and there were statistically significant differences(P<0.05).Conclusion Dabigatran has good clinical effect in small area pulmonary embolism,and can significantly improve the cardiorespiratory function of patients.