高压氧和重复经颅磁刺激应用于脑小血管病的临床价值

The Clinical Value of Hyperbaric Oxygen and Repeated Transcranial Magnetic Stimulation for Cerebrovascular Diseases

目的高压氧联合重复经颅磁刺激(rTMS)对脑小血管病伴抑郁状态患者躯体症状及认知功能的临床价值。方法选取2015年12月至2017年11月收治的98例脑小血管病伴抑郁状态患者为研究对象,分为两组,每组各49例,常规组患者实施高压氧的单独治疗,实验组患者实行高压氧和经颅磁刺激(rTMS)的联合治疗。对比两组患者的P300波幅和P300潜伏期评、MoCA评分和HAMD评分。结果治疗后,实验组P300波幅和P300潜伏期、MoCA评分和HAMD评分等多项指标均优于常规组,组间有一定的对比性,P<0.05。结论对脑小血管病伴抑郁状态患者实行高压氧和经颅磁刺激(rTMS)的联合治疗,能改善其认知功能以及躯体症状,因此可广泛推广和应用。

Objective To evaluate the clinical value of hyperbaric oxygenation combined with repetitive transcranial magnetic stimulation(rTMS)for somatic symptoms and cognitive function in patients with cerebral microvascular disease and depression.Methods A total of 98 patients with cerebral vascular disease and depressive disorder admitted from December 2015 to November 2017 were selected and divided into two groups with 49 patients in each group.The conventional group was treated with hyperbaric oxygen alone.Patients in the group were treated with hyperbaric oxygenation and transcranial magnetic stimulation(rTMS).P300 volatility and P300 latency assessment,MoCA score,and HAMD score were compared between the two groups.Results After the treatment,the P300 amplitude and P300 latency,MoCA score and HAMD score of the experimental group were all better than the conventional group.There was a certain contrast between the groups,P<0.05.Conclusion Combined treatment of hyperbaric oxygen and transcranial magnetic stimulation(rTMS)in patients with cerebral small vessel disease associated with depression can improve their cognitive function and physical symptoms,so it can be widely used and applied.