基于分子印迹技术的载药角膜接触镜研究进展

Progress in Drug-Loaded Molecularly Imprinted Contact Lenses

分子印迹角膜接触镜(MI-CL)可有效延缓药物缓释和提高眼科给药效率。它不仅能显著降低患者因滴药带来的不适感,还可反复负载相关药物,并负载大分子量药物,在临床中具有巨大的应用潜力。笔者就MI-CL的原理、发展、载药和缓释模式等做一综述,为今后新型角膜接触镜设计和临床用提供可参考的资料。

Molecularly imprinted contact lenses(MI-CL)can provide sustained drug release and improve the efficiency of ophthalmic drug delivery.They can significantly decrease the patients'discomfort caused by eye drops,but can also reload relevant drugs.More importantly,they can load high-molecular drugs.They show great potential application in the ophthalmology clinic.In this review,the principle and development,and the drug-loading model and sustained-release model of the MI-CL are included and discussed.This review can be useful for the design of novel contact lenses for clinical applications and the improvement of drug-loaded contact lenses in the future.