T_2-mapping评估成人腰椎骨髓含水量与年龄、性别的相关性

Application of T_2-mapping in the evaluation of the correlation of water content in lumbar bone marrow with age and gender in adults

目的:探讨T_2-mapping技术在评估成人腰椎骨髓含水量与年龄、性别相关性中的应用价值。方法:采用3.0T MR对78例健康志愿者行腰椎多回波SE序列T_2-mapping检查。78例志愿者中男36例,女42例,按年龄分为20~29岁、30~39岁、40~49岁、≥50岁共4组,每个年龄段又按性别分为男、女2组,共8组。测量78例志愿者L1-L5各个椎体(共390个椎体)的T_2值。对相同性别、不同年龄段及相同年龄段、不同性别的腰椎T_2值进行组间比较,并进行统计学分析。结果:相同性别、不同年龄段的腰椎T_2值比较:男性中20~29岁年龄段的腰椎T_2值均高于其它年龄段,差异均有统计学意义(P值均<0.05),其它年龄段之间差异均无统计学意义(P值均>0.05);女性中≥50岁年龄段的腰椎T_2值均低于其它年龄段,差异均有统计学意义(P值均<0.05),其它年龄段之间差异均无统计学意义(P值均>0.05)。相同年龄段、不同性别的腰椎T_2值比较:各个年龄段上女性的腰椎T_2值均高于男性,差异均有统计学意义(P值均<0.05)。结论:T_2-mapping技术可用于评估成人腰椎骨髓含水量在年龄、性别上的差异。男性与女性腰椎骨髓含水量随年龄变化规律不同,女性腰椎骨髓含水量高于男性。

Objective:To study the significance of T 2-mapping in the quantitative evaluation of the correlation of water content in lumbar bone marrow with age and gender in adults.Methods:Using 3.0T MR scan,multi-echo SE T 2-mapping imaging was performed on the lumbar spine in 78 healthy volunteers.The volunteers included 36 males and 42 females,which were divided into four groups by age(20~29y,30~39y,40~49y and≥50y),then,each group were further divided by gender,altogether there were 8 groups in this study.The T 2 values of each L 1-L 5 vertebra was measured in these 78 volunteers,with a total of 390 vertebrae.The T 2 values of lumbar vertebrae in different age groups of the same gender and that in different gender of the same age were compared respectively.Results:Comparison of lumbar T 2 values in different age groups of the same gender showing that in males,the lumbar T 2 value in the age group of 20~29y was significantly higher than that in the other age groups(P<0.05),no significant difference was existed in the other age groups(P>0.05).In females,the T 2 value of lumbar spine in the age group≥50y was significantly lower than that in the other age groups(P<0.05),no significant differences was existed in the other age groups(P>0.05).When comparison of lumbar T 2 values between different gender in the same age group were performed,the lumbar T 2 values in females were significantly higher than that in males in any age groups(P<0.05).Conclusion:T 2 mapping can be used in evaluating the differences in water content in lumbar bone marrow among different ages and between different genders in adults.The water content of lumbar bone marrow varied with age both in males and females.The water content of lumbar bone marrow in women is higher than that in men.