n-3多不饱和脂肪酸改善糖脂代谢的研究进展

Research Progress of n-3 Polyunsaturated Fatty Acids on Glucose and Lipid Metabolism

糖脂代谢的稳态调控是维持机体基本生命活动的基础,糖脂代谢的紊乱与糖尿病、肥胖、脂肪肝、心血管疾病及细胞异常增殖的发生和发展密切相关。富含生物活性n-3多不饱和脂肪酸的鱼油具有调控糖脂代谢紊乱的功能,然而其作用是复杂多方面的,目前对其靶点和分子作用机制的理解尚不全面。本文结合近年来国内外的最新研究进展,综述了n-3多不饱和脂肪酸对生物体糖代谢和脂代谢的影响。

The steady state regulation of glycolipid metabolism is the basis of maintaining the basic life activities of the body.The disorder of glycolipid metabolism is closely related to the occurrence and development of diabetes mellitus,obesity,fatty liver,cardiovascular disease and abnormal cell proliferation.Fish oil,enriched in bioactive n-3 polyunsaturated fatty acids,has therapeutic value for the treatment of glucose metabolism and lipid metabolism disorders.But the role of n-3 polyunsaturated fatty acids is complex and multifaceted,and the current understanding of its cellular targets and molecular mechanism of action is still incomplete.This review discusses recent evidence on how n-3 polyunsaturated fatty acids modify the glucose and lipid metabolism.