基于治未病的逆针灸对脂质代谢双向调控的机制浅析

Mechanism of Preventive Acupuncture and Moxibustion for Bi-directional Control of Body Fat Based on the Theory of Preventive Treatment of Disease

逆针灸是"治未病"的重要手段,指在机体未病或发病之前预先运用针灸干预来达到防治疾病的一种方法。现代研究表明,逆针灸对机体脂质代谢有明显的正性干预作用,而脂质代谢与中枢神经系统(CNS)尤其是位于下丘脑的食欲调节中枢密切相关。其调控作用的发挥是多信号、多通路的复杂过程,外围信号提供的关于摄食的信息经过大脑的集成反应以及与能量稳态相关的神经肽途径,来达到调控脂质代谢的作用。口水代谢通路是脂质代谢的重要通路,研究证明唾液内含有多种神经肽,其中许多与摄食、脂质能量代谢密切相关,而这些神经肽的相关受体,广泛分布在唾液腺或支配唾液腺的神经中。故此,本文从神经肽-口水代谢通路-食欲调节中枢轴角度探讨逆针灸对脂质代谢双向调控的机制,以期对防治脂质代谢紊乱相关疾病提供科学依据。

Preventive acupuncture and moxibustion,important interventions for preventive treatment of disease,refer to using acupuncture and moxibustion to control the risk factors to prevent the onset of disease possibly.The central nervous system(especially the appetite-regulating center in the hypothalamus),plays an important role in the regulation of lipid metabolism,a complicated process with multiple signals and pathways,demonstrating as periphery feeding signals leading to integration and coordination of brain-mediated responses and control of energy homeostasis by neuropeptide pathways.Aquaporin water channels in human salivary glands are of great significance for lipid metabolism.Studies show that saliva contains a variety of neuropeptides,many of which are closely related to feeding,lipid metabolism,and their receptors are widely distributed in the salivary glands or the nerves innervating the salivary glands.Studies support that preventive acupuncture and moxibustion are contributive to the improvement of lipid metabolism.We analyzed the mechanism of action of preventive acupuncture and moxibustion in lipid metabolism regulation from the neurobiological perspective(interpreting the role of involved neuropeptide-water channels in human salivary glands-appetite-regulating center)in an objective and scientific manner.