参葛颗粒对脾虚痰浊证老年性非酒精性脂肪性肝炎患者的临床疗效

Clinical effects of Shenge Granules on senile non-alcoholic steatohepatitis due to Spleen Deficiency and Phlegm Turbidity

目的考察参葛颗粒对脾虚痰浊证老年性非酒精性脂肪性肝炎患者的临床疗效。方法 96例患者随机分为对照组和治疗组,每组48例,对照组给予安慰剂颗粒,治疗组给予参葛颗粒,疗程24周。然后,观察2组BMI、腰臀比、肝脏超声疗效、中医证候评分和疗效、透明质酸、层粘连蛋白变化。结果与对照组比较,治疗组治疗后BMI、腰臀比、中医症候评分显著降低(P<0.05),肝脏超声、中医证候疗效显著提高(P<0.05),透明质酸、层粘连蛋白水平显著下降(P<0.01)。结论参葛颗粒对脾虚痰浊证老年性非酒精性脂肪性肝炎患者的临床疗效良好,可有效改善肝脏纤维化病变。

AIM To investigate the clinical effects of Shenge Granules on senile non-alcoholic steatohepatitis due to Spleen Deficiency and Phlegm Turbidity.METHODS Ninety-six patients randomly assigned to control group and treatment group,48 cases in each group,underwent a 24-week regimen of placebo granules and a 24-week intervention of Shenge Granules,respectively.And subsequently changes in BMI,waist-hip ratio,liver ultrasound efficacy,TCM symptom score and efficacy,hyaluronic acid and laminin in both groups were assessed.RESULTS The treatment group demonstrated significantly lower BMI,waist-hip ratio and TCM symptom score(P<0.05),remarkable improvement in liver ultrasound performance and TCM symptom efficacy assessment,and obviously less hyaluronic acid and lower laminin levels(P<0.01)after the treatment when compared with the control group.CONCLUSION Shenge Granules are clinically effective to senile non-alcoholic steatohepatitis due to Spleen Deficiency and Phlegm Turbidity in terms of improving liver fibrotic lesions.