空肠弯曲杆菌鞭毛的研究进展

Research Progress on the Flagella of Campylobacter jejuni

空肠弯曲杆菌是一种人畜共患的食物源性病原菌,可引起人和动物细菌性腹泻,且该菌的感染率逐年递增。鞭毛是细菌菌体的一种特殊结构,与菌体的运动性密切相关,有助于其躲避有害环境,同时鞭毛在细菌的致病性等方面也起着重要作用。研究发现,空肠弯曲杆菌的发病机制与鞭毛在宿主上皮细胞的定植力、黏附、侵袭力及毒素的产生密切相关。文章概述了空肠弯曲杆菌鞭毛结构、功能、调控机制及相关基因等方面的研究进展,通过归纳总结已知基因缺失突变对鞭毛的影响,从分子水平了解鞭毛的调控机制,从而探讨空肠弯曲杆菌的致病机理,以期为降低其感染率提供理论依据。

Campylobacter jejuni is a major pathogen cause of foodborne diarrhea that affects both humans and animals,and the infection rate is increased year by year.Flagella is an unique structure of the bacterial,it is associated with the motility of bacterial,and it also plays an important role in the pathogenicity.Many studies have shown that the pathogenicity of Campylobacter jejuni has a great relationship with the colonization and invasion of flagella in host epithelical cells and the production of toxins.This paper reviewed the research progress on the structure,function,regulatory mechanism and relates genes expression of flagella in Campylobacter jejuni,summed up the influence of known gene deletion mutation of Campylobacter jejuni on flagella to explore the pathogenic mechanism of Campylobacter jejuni from molecular level in order to offer theoretical basis to reduce the infection rate.