广东部分地区人群HPV持续感染影响因素研究

Influencing Factors of HPV Persistent Infection in Some Area of Guangdong Province

【目的】探讨在广东地区影响人乳头瘤病毒(HPV)持续感染的环境因素。【方法】对14 594名妇女进行HPV基因分型初筛,1年后采用方便抽样的方法重新取样检测,以两次检测结果确定持续感染组,对照组则由HPV初筛阳性转阴性和第1或第2次HPV筛查结果为阴性的人群组成。通过流行病学调查问卷收集研究对象基本信息,分析环境因素与HPV持续感染之间的相关性。【结果】首次筛查HPV阳性人数为1 050人,阳性率为7.21%(1 050/14 559)。1年后复检,共309名研究对象存在HPV持续感染,检测出16种HPV持续感染亚型,持续感染排在前4位的HPV亚型分别是HPV52(28.2%)、HPV58(18.8%)、HPV16(17.2%)、HPV18(11.0%)。非条件Logistic回归分析结果显示:怀孕次数(OR=2.10,95%CI=1.64~2.70,P=0.000)、初孕年龄(OR=1.39,95%CI=1.13~1.71,P=0.002)和同房前后清洗习惯(OR=0.48,95%CI=0.38~0.60,P=0.000)是HPV持续感染的独立影响因素。【结论】怀孕次数多和初孕年龄大是发生HPV持续感染的危险因素,同房前后清洗习惯能够降低HPV持续感染风险。

【Objective】To investigate the environmental factors that may affect the persistent infection of human papil-lomavirus(HPV)in Guangdong Province.【Methods】A total of 14594 women were screened for HPV genotyping.One year later,convenience sampling method was used to choose the subjects to screen for HPV genotyping as well.Consequently,subjects were defined as HPV persistent infection group according to the results of above two screenings.The control group consisted of people who were screened initially positive to negative,and negative in the first or second HPV screening.Epi-demiological questionnaire was used to collect the basic information of the subjects to analyze the correlation between envi-ronmental factors and HPV persistent infection.【Results】A total of 1 050 people were screened with HPV-positive initial-ly,with positive rate of 7.21%(1050/14559).After one year follow-up study,a total of 309 subjects had HPV persistent infection.A total of 16 subtypes of HPV persistent infection were detected.The top four HPV subtypes were HPV52(28.2%),HPV58(18.8%),HPV16(17.2%)and HPV18(11.0%),respectively.Logistic regression analysis showed that the times of pregnancy(OR=2.10,95%CI=1.64~2.70,P=0.000),first gestational age(OR=1.39,95%CI=1.13~1.71,P=0.002),and sexual hygiene(OR=0.48,95%CI=0.38-0.60,P=0.000)were the independent influential factors of HPV persistent infection.【Conclusion】The increasing times of pregnancy and first gestational age increasing both were the risk factors of HPV persistent infection.Sexual hygiene could reduce the risk of HPV persistent infection.