运动对动脉粥样硬化斑块逆转机制的研究进展

The Progress of Reversal Mechanism of atherosclerosis by Exercise

众所周知,动脉粥样硬化是多种临床突发性心血管疾病的病理基础,随着人们对疾病机理研究和诊断技术的不断提高,关于动脉粥样硬化斑块的控制和稳定技术已经比较成熟,而动脉粥样硬化斑块逆转成为了新的研究热点。大量研究表明,运动干预是动脉粥样硬化斑块逆转的有效途径,相较于药物治疗具有更加广泛的指导意义。研究从运动对血脂改善、氧化应激反应、炎症反应、防止斑块扩大和破裂以及运动与斑块逆转的"剂量-反应关系"5个方面阐述了运动对动脉粥样硬化斑块逆转的机制,以及运动干预后斑块的形态学和组成成分方面的逆转性改变,系统探讨了运动与动脉粥样硬化斑块逆转之间的关系。

As we all know,atherosclerosis is the pathological basis of many clinical sudden cardiovascular diseases.With the continuous improvement of research on disease mechanisms and diagnostic techniques,the control and stabilization of atherosclerotic plaque has become mature,and the reversal of atherosclerotic plaque has become a new research hotspot.A large number of studies have shown that exercise intervention is an effective approach to the reversal of atherosclerotic plaque and has more instruction significance than drug therapy.This article discusses the mechanism of reversal of atherosclerotic plaque by exercise,and the reversal of plaque in morphology and composition after exercise intervention,from five aspects:blood lipid improvement,oxidative stress response,inflammatory response,prevention of plaque enlargement and rupture,and the“doseresponse relationship”between exercise and plaque reversal.The relationship between exercise and the reversal of atherosclerotic plaques was systematically investigated.