吡啶甲酸铬衍生物的合成、安全性及降糖活性

Syntheses, Safety and Antihyperglycemic Effects of Chromium Picolinate Derivatives

合成了4种新型吡啶甲酸铬衍生物并通过单晶衍射、电喷雾质谱、元素分析、电导率及红外光谱等手段对其结构进行了表征。通过循环伏安法研究了配体对配合物氧化还原活性的影响,通过Fenton-like反应观察了配合物诱发产生自由基的程度,发现其中有3个配合物诱发产生的自由基少于市售产品吡啶甲酸铬Cr(pic)3。动物活体实验表明,高剂量配合物3不会对小鼠脏器造成明显损伤,低剂量喂食能降低糖尿病小鼠的空腹血糖及低密度脂蛋白,其效果优于Cr(pic)3。

Four new chromium picolinate derivatives were synthesized and characterized by X-ray crystal diffraction,ESI-MS,analytical element,conductivity and IR analysis.The effect of substituent groups on its redox property and hydroxyl radical(·OH)generation induced by the complex were investigated by cyclic voltammetry and Fenton-like reaction.As a result,three complexes generate less·OH than Cr(pic)3.Besides,acute toxicity and antihyperglycemic effect indicated that high dose of complex 3 is hypotoxic and exhibited more efficiency than Cr(pic)3 in reducing fasten blood glucose(FBG)and low density lipoprotein by low dose.CCDC:1500277,3.