靶控输注舒芬太尼复合丙泊酚麻醉对高血压全麻患者应激反应的影响分析

Impact analysis of target controlled infusion of Sufentanil combined with Propofol anesthesia on stress response in patients with hypertension under general anesthesia

目的分析靶控输注(TCI)舒芬太尼复合丙泊酚麻醉对高血压全身麻醉(全麻)患者应激反应的影响。方法 64例接受高血压全麻手术的患者,随机分为研究组与参照组,每组32例。参照组应用静脉注射芬太尼与丙泊酚麻醉,研究组应用靶控输注舒芬太尼与丙泊酚麻醉。对比两组患者插管前后的平均动脉压、心率;呼吸恢复时间、睁眼时间、拔管时间。结果插管前,两组患者的平均动脉压、心率对比差异无统计学意义(P>0.05);插管后,研究组患者的平均动脉压、心率均高于参照组,差异具有统计学意义(P<0.05)。研究组患者的呼吸恢复时间(4.72±1.73)min、睁眼时间(5.63±1.82)min及拔管时间(7.19±1.33)min均短于参照组的(6.87±2.68)、(7.76±2.17)、(10.02±3.02)min,差异具有统计学意义(P<0.05)。结论靶控输注舒芬太尼复合丙泊酚麻醉,高血压全麻患者术中应激反应较轻,有助于手术治疗的有序开展,麻醉药物应用效果更加理想。

Objective To analyze the impact of target controlled infusion(TCI)of Sufentanil combined with Propofol anesthesia on stress response in patients with hypertension under general anesthesia.Methods A total of 64 hypertension patients with general anesthesia surgery were randomly divided into research group and reference group,32 cases in each group.The reference group received intravenous injection of Fentanyl and Propofol for anesthesia,the research group received target controlled infusion of Sufentanil and Propofol for anesthesia.The mean arterial pressure and heart rate before and after intubation,respiratory recovery time,eye opening time and extubation time between the two groups were compared.Results There were no significant differences in the mean arterial pressure and heart rate between the two groups before intubation(P>0.05).After intubation,the mean arterial pressure and heart rate of the research group were significantly higher than those of reference group,the difference was statistically significant(P<0.05).The respiratory recovery time,eye opening time and extubation time of research group were(4.72±1.73)min,(5.63±1.82)min and(7.19±1.33)min,which were significantly shorter than(6.87±2.68)min,(7.76±2.17)min and(10.02±3.02)min,the differences were statistically significant(P<0.05).Conclusion The implementation of TCI of Sufentanil combined with Propofol anesthesia,the stress response in patients with hypertension under general anesthesia is relatively light,which is conducive to the orderly development of surgical treatment,and the application effect of anesthetic drugs is more ideal.