寄生虫治疗狼疮性肾炎的研究进展

Progress in treatment of lupus nephritis by parasites

寄生虫感染与自身免疫性疾病发展之间的反比关系是卫生假说的基石,许多学者对寄生虫防治自身免疫性疾病进行了研究,其中包括系统性红斑狼疮性肾炎,我们从免疫机制、遗传背景、寄生虫的种类及提取物、临床病例启示等方面对寄生虫尤其是蠕虫干预狼疮性肾炎的研究进展做以综述,为早日研发出防治狼疮性肾炎乃至其他免疫失衡性疾病的新型生物制剂奠定实验与理论基础。

The inverse relationship between parasitic infection and the development of autoimmune diseases is the cornerstone of the hygiene hypothesis.Many scholars have studied the prevention and treatment of parasites from autoimmune diseases,including systemic lupus erythematosus nephritis.This paper reviews the progress of the research on the intervention of parasite,especially in lupus nephritis from the aspects of immune mechanism,genetic background,species and extract of parasite,clinical case inspiration.It lays the experimental and theoretical foundation to study new biological agents for preventing and treating lupus nephritis and other immune imbalance diseases.